Protein Info for IAI46_05310 in Serratia liquefaciens MT49

Annotation: copper-exporting P-type ATPase CopA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 906 transmembrane" amino acids 261 to 279 (19 residues), see Phobius details amino acids 290 to 310 (21 residues), see Phobius details amino acids 322 to 343 (22 residues), see Phobius details amino acids 356 to 374 (19 residues), see Phobius details amino acids 508 to 530 (23 residues), see Phobius details amino acids 536 to 558 (23 residues), see Phobius details amino acids 850 to 869 (20 residues), see Phobius details amino acids 875 to 896 (22 residues), see Phobius details PF00403: HMA" amino acids 7 to 62 (56 residues), 36.2 bits, see alignment 1.6e-12 amino acids 74 to 128 (55 residues), 36.7 bits, see alignment 1.1e-12 amino acids 177 to 231 (55 residues), 58.6 bits, see alignment 1.7e-19 TIGR01511: copper-translocating P-type ATPase" amino acids 305 to 899 (595 residues), 628.9 bits, see alignment E=2.3e-192 TIGR01525: heavy metal translocating P-type ATPase" amino acids 324 to 899 (576 residues), 614.2 bits, see alignment E=6.7e-188 TIGR01494: HAD ATPase, P-type, family IC" amino acids 363 to 869 (507 residues), 296.1 bits, see alignment E=9.4e-92 PF00122: E1-E2_ATPase" amino acids 392 to 572 (181 residues), 176 bits, see alignment E=1.4e-55 PF00702: Hydrolase" amino acids 590 to 804 (215 residues), 142.7 bits, see alignment E=4.8e-45 PF12710: HAD" amino acids 719 to 800 (82 residues), 27 bits, see alignment E=1.4e-09 PF08282: Hydrolase_3" amino acids 776 to 836 (61 residues), 29.9 bits, see alignment 1.2e-10

Best Hits

Swiss-Prot: 74% identical to COPA_ECOLI: Copper-exporting P-type ATPase (copA) from Escherichia coli (strain K12)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 76% identity to eca:ECA1193)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (906 amino acids)

>IAI46_05310 copper-exporting P-type ATPase CopA (Serratia liquefaciens MT49)
MSQTTVLALQGLTCMNCAQRVKKALESREDVEQAEVNVHYAKVTGEASSQALIDSVVAAG
YQAAVAQQPDTELQLNGLSCMHCAASTRKALEAVPGVIAADVSIDSAKVYGDAASEALIA
AVEDAGYHASLAGAATSPKTEPLTESVPVLPETQATASSPLPATSNGDDDDSVQLLLSGM
SCASCVSKVQNALQSVSGVDQARVNLAERSALITGSADPQALVAAVEKAGYGAEMIQDET
ERRERQQQTAQANMKRFRWQAALGLALGIPLMAWGLFGGSMSLTPETQRPWLLVGLLTLA
VMVFAGGHFYRNAWRALMNGSATMDTLVALGTGAAWLYSISVNLWPDFFPMAARHLYYEA
SAMIIGLINLGHALEQRARQRSSQALERLLDLTPPTARLVTDDGEKNIPLAQVQLGMTLR
LTTGDRIPVDGEIIQGEVWLDEAMLTGEAVPQQKSVGDTVHAGTVVDDGSVLFRAGAIGS
KTTLARIIKLVRQAQSSKPEIGKLADRISAVFVPTVVAIALFSAAIWYFFGPQPQLVYTL
VIATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRDADALQQASQLDTLVFDKTGTL
TEGQPRVVEILTFNQVSDQQALRWAAALEQGASHPLARAIVDHAEGQALPQVEQFRTLRG
AGVSGEVDGMKLLLGNAALLQQHQVATAELDTQMQQQAERGITPVLLAVEGKPAALFAIR
DPLRRDSVEALQRLHRQGYQLVMLTGDNPVTANAIAKEAGIDRVIAGVLPEGKAEAIKQL
QAQGHRVAMIGDGINDAPALAQADVGIAMGGGSDIAIETAAITLMRHSLNGVADALELSK
ATLRNMKQNLLGAFVYNTLGIPIAAGVLYPLTGTLLSPVVAGAAMALSSITVVSNANRLL
RFKPKR