Protein Info for IAI46_04975 in Serratia liquefaciens MT49

Annotation: cytochrome o ubiquinol oxidase subunit III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00510: COX3
  • amino acids 17 to 202 (186 residues), 53.1 bits, E=2.3e-18
• TIGR02842: cytochrome o ubiquinol oxidase, subunit III
  • amino acids 25 to 204 (180 residues), 293.8 bits, E=3.4e-92

Best Hits

Swiss-Prot: 76% identical to CYOC_ECOLI: Cytochrome bo(3) ubiquinol oxidase subunit 3 (cyoC) from Escherichia coli (strain K12)

KEGG orthology group: K02299, cytochrome o ubiquinol oxidase subunit III [EC: 1.10.3.-] (inferred from 97% identity to srs:SerAS12_1001)

MetaCyc: 76% identical to cytochrome bo3 subunit 3 (Escherichia coli K-12 substr. MG1655)
RXN-21817 [EC: 7.1.1.3]

Predicted SEED Role

"Cytochrome O ubiquinol oxidase subunit III (EC 1.10.3.-)" in subsystem Terminal cytochrome O ubiquinol oxidase or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

• D-lactate to cytochrome bo oxidase electron transfer (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer II (1/2 steps found)
• glycerol-3-phosphate to cytochrome bo oxidase electron transfer (1/2 steps found)
• proline to cytochrome bo oxidase electron transfer (1/2 steps found)
• pyruvate to cytochrome bo oxidase electron transfer (1/2 steps found)
• succinate to cytochrome bo oxidase electron transfer (1/2 steps found)

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.3

Protein Sequence (205 amino acids)

>IAI46_04975 cytochrome o ubiquinol oxidase subunit III (Serratia liquefaciens MT49)
MSTDTLTNHNAAHAEHGHHDAGETKVFGFWIYLMSDCILFASLFATYAVLVNGTAGGPSG
KDIFDLKFVLVETFLLLFSSITYGMAMIGMNKGKVSSVNTWLFLTFLFGLGFVAMEIYEF
HHLIVEGYGPDRSAFLSSFFALVATHGLHVTTGLVWIIIMMIQVSKRGLTATNKTRLMCL
SLFWHFLDVVWICVFTVVYLLGVMS