Protein Info for IAI46_04605 in Serratia liquefaciens MT49

Annotation: class I SAM-dependent methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 256 PF01209: Ubie_methyltran" amino acids 20 to 158 (139 residues), 71.5 bits, see alignment E=3.5e-23 PF07021: MetW" amino acids 33 to 138 (106 residues), 28 bits, see alignment E=7.9e-10 PF13489: Methyltransf_23" amino acids 35 to 194 (160 residues), 66.8 bits, see alignment E=9.8e-22 PF05175: MTS" amino acids 37 to 169 (133 residues), 34.3 bits, see alignment E=9.5e-12 PF03848: TehB" amino acids 39 to 145 (107 residues), 22.6 bits, see alignment E=3.2e-08 PF13847: Methyltransf_31" amino acids 47 to 150 (104 residues), 84.6 bits, see alignment E=3.1e-27 PF03141: Methyltransf_29" amino acids 49 to 145 (97 residues), 28.5 bits, see alignment E=3.1e-10 PF08242: Methyltransf_12" amino acids 50 to 143 (94 residues), 66.4 bits, see alignment E=1.6e-21 PF13649: Methyltransf_25" amino acids 50 to 142 (93 residues), 90.1 bits, see alignment E=6.2e-29 PF08241: Methyltransf_11" amino acids 50 to 146 (97 residues), 100.7 bits, see alignment E=2.9e-32

Best Hits

KEGG orthology group: None (inferred from 91% identity to srs:SerAS12_0933)

Predicted SEED Role

"SAM-dependent methyltransferase YafE (UbiE paralog)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (256 amino acids)

>IAI46_04605 class I SAM-dependent methyltransferase (Serratia liquefaciens MT49)
MSNSNSHKNAVDRQFGEQANAYLTSAVHAQGKDLQRLAQLLEPYPDARLLDLGCGAGHAS
FSAAAKVAQVVAYDLSAQMLAVVSQTAVEKGFNNIQVQQGVAESLPFEDASFDLVISRYS
AHHWHDVGQALREVRRVLKPGGRAIFMDVVSPGHPLLDIYLQTVEVLRDTSHVRNYAPGE
WLGLLTESGLLVREVTSDRLYLEFSSWVARMRTPEHFVTAIRALQQGVSEEVQQHFAIQP
DGSFTSDIMMFEAVRG