Protein Info for IAI46_04275 in Serratia liquefaciens MT49

Annotation: allantoate amidohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01879: amidase, hydantoinase/carbamoylase family
  • amino acids 25 to 412 (388 residues), 387.4 bits, E=3.9e-120
• PF04389: Peptidase_M28
  • amino acids 68 to 150 (83 residues), 33 bits, E=7.6e-12
• PF01546: Peptidase_M20
  • amino acids 84 to 412 (329 residues), 73.8 bits, E=2.8e-24
• PF07687: M20_dimer
  • amino acids 218 to 318 (101 residues), 27.2 bits, E=4.9e-10

Best Hits

KEGG orthology group: K02083, allantoate deiminase [EC: 3.5.3.9] (inferred from 89% identity to spe:Spro_0937)

Predicted SEED Role

"N-carbamoyl-L-amino acid hydrolase (EC 3.5.1.87)" in subsystem Hydantoin metabolism (EC 3.5.1.87)

MetaCyc Pathways

• allantoin degradation to ureidoglycolate II (ammonia producing) (2/4 steps found)
• allantoin degradation to glyoxylate II (2/5 steps found)
• allantoin degradation to glyoxylate III (2/5 steps found)
• allantoin degradation IV (anaerobic) (4/9 steps found)
• superpathway of allantoin degradation in plants (3/8 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.87

Use Curated BLAST to search for 3.5.1.87 or 3.5.3.9

Protein Sequence (424 amino acids)

>IAI46_04275 allantoate amidohydrolase (Serratia liquefaciens MT49)
MALRLTVQEAEQAAARVMARCDALAAISATPGQLTRVYLSPEHRRANLLVGDWMRSIGMR
VWQDAVGNVCGRYEGQTPGAPALLLGSHLDTVRNAGRYDGMLGVLTALEVVAHLHQQQRR
LPVAVEVIGFADEEGTRFSVALLGSRGITGQWPAEWLARTDAEGISVAQALREFGLDPAA
VVEARRAPGDICAYLELHIEQGPCLEAADLALGVVTAINGARRLHCTFSGEAGHAGTVPM
GQRKDALAAAAEWMVAVEAITRTRDEHLVATVGCIESLPGAVNVIPGEVKLSLDVRGPQD
GPLAALLTQLLERAQEICARRGLGFASEEFYRINATECDADLQQRWQQSVAAVQGSSMAL
PSGAGHDAIAVAACWPVGMLFVRCDRGISHHPAEAVSQTDVALAIQAYCQTVASWENTDE
PAAV