Protein Info for IAI46_04055 in Serratia liquefaciens MT49

Annotation: acyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 transmembrane" amino acids 57 to 72 (16 residues), see Phobius details PF00501: AMP-binding" amino acids 26 to 294 (269 residues), 46 bits, see alignment E=3.5e-16 PF13193: AMP-binding_C" amino acids 349 to 432 (84 residues), 35.5 bits, see alignment E=1.5e-12

Best Hits

KEGG orthology group: None (inferred from 83% identity to spe:Spro_0893)

Predicted SEED Role

"FIGfam138462: Acyl-CoA synthetase, AMP-(fatty) acid ligase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (443 amino acids)

>IAI46_04055 acyl-CoA synthetase (Serratia liquefaciens MT49)
MNRWLSTQRDDSVPIAWRGDQLFCLGQFRRDVAALAAILASREEHRWALCFDDSYRFAVA
LLASLYAGRLPVIFGHQREAILKEQRADYDALLTDLPLDPGVPVLTVREGGCEDIALPAW
PQDPRFILYTSGSTGQPQAVCKSVACMDRESELLAAAFGDVFRGCRVVASVSHQHMYGLS
FRLFLPLALGLPFDAQLTQYQEQLIARHQGRRLVFVSSPAWLKRLDNRLTLAECVEVFSA
GGPLSEVEAQLARQMLGVLPLEIYGTTETGSLAWRRQNRDIALWHPFACVRLRVDSDHRI
EVVSPLIPDTGKTLLSDIIELAPDGRQFQLNGRADRIIKLEEKRLSLTEVERRLVALPEV
ADAAVLTQQQRGRTLLVAVVVLSPYGELRRQTLSEGAFTRELHQALRGWLEPVALPRSWR
IIDAIPLNPQGKRAYAELQELFL