Protein Info for IAI46_03635 in Serratia liquefaciens MT49

Annotation: histidine ammonia-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 46% identical to HUTH_SYMTH: Histidine ammonia-lyase (hutH) from Symbiobacterium thermophilum (strain T / IAM 14863)

KEGG orthology group: K01745, histidine ammonia-lyase [EC: 4.3.1.3] (inferred from 90% identity to spe:Spro_0799)

MetaCyc: 41% identical to histidase subunit (Pseudomonas putida)
Histidine ammonia-lyase. [EC: 4.3.1.3]

Predicted SEED Role

"Histidine ammonia-lyase (EC 4.3.1.3)" in subsystem Histidine Degradation (EC 4.3.1.3)

MetaCyc Pathways

L-histidine degradation II (5/5 steps found)
L-histidine degradation VI (7/8 steps found)
L-histidine degradation I (4/4 steps found)
L-histidine degradation III (4/6 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.3.1.3

Use Curated BLAST to search for 4.3.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (507 amino acids)

>IAI46_03635 histidine ammonia-lyase (Serratia liquefaciens MT49)
MHYPSSVEIDRQPLRWQDVVAVARQRVPLSLSDAAWARIENAQAIVQQIVTSEQRAYGVN
TGLGALCNQALHGEQLAQLSRNTLMSHACGVGTPLSDEQTRAIICCAIVNYSHGKSGIHR
SVVEALLALLNHGVTPQVPSQGSVGYLTHMAHVGVALLGLGEVSYRGQIVAAAQALAEEG
IALPPLGAKDGLCLVNGTPCMTGLSCLALADAWRLARWADVLGAMSFEALRGQIAAFDEE
ILALKPHPGMQRVGANLRALLHGSEVIAASKGIRTQDALSIRSIPQVHGACRDQMAHAER
QIETELNGTTDNPLLLGTPDNFRVMSQANPHGESVAMAADMLAIAIAELGGIAERRIDRL
INPLVSGLPPFLVSEPGVNSGMMIAQYVAASLCAENRQLAQPCVVDNYVTSALQEDHLSL
GTGAALRLHKLLANVNQILAIEYLLAAQAFEFLQPQRFGEGTGRAWRLLRQRVEPYHQDR
WLAPDIASSAALLQDEQALAEIAPALN