Protein Info for IAI46_03605 in Serratia liquefaciens MT49

Annotation: nucleoside triphosphate pyrophosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00444: MazG family protein
  • amino acids 13 to 260 (248 residues), 372.5 bits, E=5.3e-116
• PF01503: PRA-PH
  • amino acids 28 to 92 (65 residues), 22.5 bits, E=1.2e-08
• PF03819: MazG
  • amino acids 30 to 103 (74 residues), 99.2 bits, E=1.3e-32
  • amino acids 170 to 232 (63 residues), 34.4 bits, E=2.2e-12

Best Hits

Swiss-Prot: 75% identical to MAZG_ECO57: Nucleoside triphosphate pyrophosphohydrolase (mazG) from Escherichia coli O157:H7

KEGG orthology group: K02428, nucleoside-triphosphate pyrophosphatase [EC: 3.6.1.19] (inferred from 97% identity to spe:Spro_0793)

MetaCyc: 75% identical to nucleoside triphosphate pyrophosphohydrolase (Escherichia coli K-12 substr. MG1655)
Nucleotide diphosphatase. [EC: 3.6.1.9]

Predicted SEED Role

"Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8)" (EC 3.6.1.8)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (14/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (7/7 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides dephosphorylation (2/3 steps found)
• dZTP biosynthesis (3/5 steps found)
• tunicamycin biosynthesis (2/9 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Nicotinate and nicotinamide metabolism
• Pantothenate and CoA biosynthesis
• Purine metabolism
• Pyrimidine metabolism
• Riboflavin metabolism
• Starch and sucrose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.19 or 3.6.1.8 or 3.6.1.9

Protein Sequence (264 amino acids)

>IAI46_03605 nucleoside triphosphate pyrophosphohydrolase (Serratia liquefaciens MT49)
MTQSSPLHRLLNIMKTLRDPQVGCPWDRKQTFATIAPYTLEETYEVLDAIERQDYGDLRD
ELGDLLFQVVFYAQMGQEQGLFDFDEVCNAISDKLERRHPHIFGEADAADSEAVAARWEQ
LKAGERAEKALHSALDDIPQALPALMKAHKIQKRCASVGFDWHTLGPVLDKVYEEIDEVM
HEAQQAVVDEQKLEEEIGDLLFATVNLSRHLGHKAENALQAANRKFERRFRQVEEIIQQR
GLQMGEATLEQMEEAWQQVKRQEN