Protein Info for IAI46_03600 in Serratia liquefaciens MT49

Annotation: GTP diphosphokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 743 PF13328: HD_4" amino acids 46 to 191 (146 residues), 148.8 bits, see alignment E=3.3e-47 TIGR00691: RelA/SpoT family protein" amino acids 64 to 739 (676 residues), 623.3 bits, see alignment E=2.7e-191 PF04607: RelA_SpoT" amino acids 251 to 360 (110 residues), 144.5 bits, see alignment E=4.5e-46 PF02824: TGS" amino acids 405 to 464 (60 residues), 77.3 bits, see alignment 2.2e-25 PF19296: RelA_AH_RIS" amino acids 483 to 645 (163 residues), 48.8 bits, see alignment E=2.9e-16 PF13291: ACT_4" amino acids 663 to 739 (77 residues), 63.9 bits, see alignment E=5.3e-21 PF01842: ACT" amino acids 667 to 732 (66 residues), 41.4 bits, see alignment E=3e-14

Best Hits

Swiss-Prot: 85% identical to RELA_ECOL6: GTP pyrophosphokinase (relA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K00951, GTP pyrophosphokinase [EC: 2.7.6.5] (inferred from 87% identity to ddc:Dd586_3328)

MetaCyc: 85% identical to GDP/GTP pyrophosphokinase (Escherichia coli K-12 substr. MG1655)
GTP diphosphokinase. [EC: 2.7.6.5]; 2.7.6.5 [EC: 2.7.6.5]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.6.5

Use Curated BLAST to search for 2.7.6.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (743 amino acids)

>IAI46_03600 GTP diphosphokinase (Serratia liquefaciens MT49)
MVAVRSAHLNTAGEFALDEWIASLGLPNPQSCERLAATWRYCEQQTQNHPNAPLLLWRGL
EMVEILSTLSMDNDSMRAALLFPLVDAGIVQEETLTEEFGKGITYLVHGVRDMDAIRQLK
ATQNDSMASEQVDNVRRMLLAMVEDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECSN
IYAPLANRLGIGQLKWELEDFCFRYLHPDEYKRIAKLLHERRIDREQFIDDFVASLRNAM
VDEGVKADIYGRPKHIYSIWRKMQKKALAFDELFDVRAVRVVVERLQDCYAALGIVHTHF
RHLPDEFDDYVANPKPNGYQSIHTVVLGPRGKTLEIQIRTRQMHEDAELGVAAHWKYKEG
AVATVRSGYEERIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAG
STPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLRMGDQIEIITQKQPNPSRDWLNPNLG
YITTSRGRSKIHNWFRKQDRDKNILAGRQMLDSELEHLGISLKEAEKLLIPRYNMNSLDE
ILAAIGGGDIRLNQMVNFLQGKFNKPSAEEQDREALRQLVQQKAPPATRSKDNGRVVVEG
VGNLMHHIARCCQPIPGDDIIGFITQGRGISIHRADCDQLVDLQSHAPERIVDAVWGESY
SSGYSLVVRVMANDRSGLLRDITTILANEKVNVLGVASRSDTKKQLATIDMDIEIYNQQV
LGRVLAKLNQLPDVIDAKRLHGS