Protein Info for IAI46_03590 in Serratia liquefaciens MT49

Annotation: two-component sensor histidine kinase BarA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 910 signal peptide" amino acids 10 to 11 (2 residues), see Phobius details transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 176 to 198 (23 residues), see Phobius details PF09984: sCache_4" amino acids 31 to 176 (146 residues), 191.2 bits, see alignment E=2.5e-60 PF00672: HAMP" amino acids 197 to 247 (51 residues), 32.1 bits, see alignment 3.4e-11 PF00512: HisKA" amino acids 292 to 356 (65 residues), 73.5 bits, see alignment 3.4e-24 PF02518: HATPase_c" amino acids 403 to 517 (115 residues), 96 bits, see alignment E=6e-31 PF00072: Response_reg" amino acids 666 to 776 (111 residues), 88.5 bits, see alignment E=1e-28 PF01627: Hpt" amino acids 820 to 899 (80 residues), 43.5 bits, see alignment E=9.1e-15

Best Hits

Predicted SEED Role

"BarA sensory histidine kinase (= VarS = GacS)" in subsystem Type III secretion system orphans

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (910 amino acids)

>IAI46_03590 two-component sensor histidine kinase BarA (Serratia liquefaciens MT49)
MTKYSLRARMMILILAPTLLIGLLLSTFFVVHRYNELQEQLVDAGASIIEPLAVASEYGM
TFRSRESVRQLVSLLHRRHSDIVRSITVFDAQNNLFVTSNYHHNFTQLQLPKGVPIPTDL
MLTRRGDSLILRTPILAESQYPDQAASSDLQQDNRLGYVAIELDLQSVRLQQYKEVFVST
LLLLLCMCIAILFAYRLMRDVTGPIRNMVNTVDRIRRGQLDSRVEGFMLGELHMLKNGIN
SMAMSLTAYHEEMQQNIDQATSDLRETLEQMEIQNVELDLAKKRAQEAARIKSEFLANMS
HELRTPLNGVIGFTRQMLKTEMSVTQTDYLQTIERSANNLLTIINDVLDFSKLEAGKLVL
EHIPFSLRETLDEVIVLLAPSAHEKGLELTLDVHNDVPEQVIGDSLRLQQIITNLLGNAI
KFTETGNIDIRVELRGLQDRQIELEVQIHDTGIGISERQQSQLFQAFRQADASISRRHGG
TGLGLVITQKLVKEMGGDICFHSQLNRGSTFWFHITLDLHEGMLSLPPSLPDLQGKTLGY
IEANPMAAQATLNMLNVTQLVITHSPTLAQLPKKHYDFLLVGVPIPFRDNMAQHESKLLA
ALKVADRVILALPCQSQINAEMLKQQGAAGCLIKPITSNRLFPLLRMETPPRITALPERK
RLPLTVMAVDDNPANLKLIGTLLAEQVEKTLLCESGEEALLLARDNVLDLILMDIQMPNI
DGIRTSELIRQLPHHNSTPIVAVTAHAVSGEREHLLQAGMDDYLAKPIDEAMLTRVLARY
HSGEPDPVTPAPVSVNEPPLSLDWALALRQAANKPDLARDLLQMLLDFLPQVSERVQAML
DGTPDADILDLIHKLHGSCSYSGVPRLKQLCFYIEQQLRRGVSSDDLEPEWLELLDEIEL
VCQAARAHLA