Protein Info for IAI46_03550 in Serratia liquefaciens MT49

Annotation: H(+)/Cl(-) exchange transporter ClcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 479 transmembrane" amino acids 33 to 53 (21 residues), see Phobius details amino acids 74 to 97 (24 residues), see Phobius details amino acids 127 to 145 (19 residues), see Phobius details amino acids 177 to 201 (25 residues), see Phobius details amino acids 213 to 232 (20 residues), see Phobius details amino acids 252 to 272 (21 residues), see Phobius details amino acids 291 to 309 (19 residues), see Phobius details amino acids 328 to 348 (21 residues), see Phobius details amino acids 356 to 377 (22 residues), see Phobius details amino acids 388 to 413 (26 residues), see Phobius details amino acids 421 to 440 (20 residues), see Phobius details PF00654: Voltage_CLC" amino acids 90 to 437 (348 residues), 324.7 bits, see alignment E=3.9e-101

Best Hits

Swiss-Prot: 80% identical to CLCA_SALCH: H(+)/Cl(-) exchange transporter ClcA (clcA) from Salmonella choleraesuis (strain SC-B67)

KEGG orthology group: K03281, chloride channel protein, CIC family (inferred from 96% identity to spe:Spro_0782)

MetaCyc: 71% identical to chloride:H+ antiporter ClcA (Escherichia coli K-12 substr. MG1655)
RXN0-2501

Predicted SEED Role

"H(+)/Cl(-) exchange transporter ClcA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (479 amino acids)

>IAI46_03550 H(+)/Cl(-) exchange transporter ClcA (Serratia liquefaciens MT49)
MTELQQQPRVAQAPRLKRSDAVRQLLRRDKTPVAILFMAALVGTMAGLLGVAFDKAVDWV
QQQRFSALAQVADYWILVWPLAFILSAALAMLGYYLVRRFAPEAGGSGIPEIEGALEELR
PVRWWRVIPVKFIGGMGTLGAGMVLGREGPTVQMGGNVGRMVLDIFRMRGAEARHSLLAT
GAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFIGVIMSSVVFQLFNGEGSVIA
VGKLSSAPINTLWLYLVLGAIFGAVGVMFNALVFRTQDMFARLHGGKMRKILLMGGLLGG
ICGILGLIQPEAAGGGFGLIPIAAAGNYSVGMLMFIFITRVITTLLCFGSGAPGGIFAPM
LALGTLFGTAFGLAGGHLFPEYGIEAGTFAIAGMGALFAATVRAPLTGIVLVLEMTDNYQ
LILPMIITCLGATLVAQFLGGKPLYSSILARTLQRQEASQASEAADKTGKENTTNAVNT