Protein Info for IAI46_03260 in Serratia liquefaciens MT49

Annotation: LPS assembly protein LptD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 787 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF03968: LptD_N" amino acids 52 to 193 (142 residues), 81.3 bits, see alignment E=9.2e-27 PF19838: LptD_2" amino acids 200 to 333 (134 residues), 30.3 bits, see alignment E=2.8e-11 PF04453: LptD" amino acids 305 to 700 (396 residues), 376.2 bits, see alignment E=3.6e-116

Best Hits

Swiss-Prot: 77% identical to LPTD_YERE8: LPS-assembly protein LptD (lptD) from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

KEGG orthology group: K04744, LPS-assembly protein (inferred from 68% identity to ddc:Dd586_3570)

MetaCyc: 68% identical to LPS assembly protein (Salmonella enterica enterica serovar Typhimurium str. LT2)
RXN1R65-51 [EC: 7.5.2.5]

Predicted SEED Role

"Outer membrane protein Imp, required for envelope biogenesis / Organic solvent tolerance protein precursor"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.5.2.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (787 amino acids)

>IAI46_03260 LPS assembly protein LptD (Serratia liquefaciens MT49)
MKKSFPTLLATLIWTALYSQHALADLAEQCMLGVPVYDKPLVSGDPNSLPVTIHADDSRA
DYPKSALFTGNVNIEQGNSTLTAKQVELNQTQDAGQTEPVRTVTATGDVHYSDNQIKLKG
PKAWSNLNNKDTDVYQGDYQMVGRQGRGDADKMKMRGANRYTILENGTFTSCLPGDNSWS
VVGSEVIHDREEQVAEIWNARFKIGGVPVFYSPYLQLPVGDKRRSGFLIPNAKYGSSNGF
EFMLPYYWNIAPNFDATITPHYMSKRGLQLQNEFRYLVQPGLGLMELDWLPDDKEYSKDN
PDDSKRWLFYWNHNGVMDQVWRFNVDYTKVSDSKYFTDLDSKYGSTTDGYATQKFSVGYA
IDNWDATLSSKQFQIYDDTDRSSSDSYKVQPQLDLNYYKEDLGPFDFRIYGQAAKFISVN
PYSPDATRLHMEPTLSLPLTNGWGSINTEAKLLATHYQQDIPDGFANNYKNRTGSDAPDL
EDSVNRVLPQFKVDGKMVFDRPMNWSEGYTQTLEPRVQYLYVPYRDQSNIYTYDTTLLQT
DYSGLFRDRTYSGLDRIASQNRVSTGLTSRIYDDALVERFNVSVGQIYYFSRSRTGDKTT
NYDNNDDTGSLAWAGDTYWKIDDRWGLRGGLQYDTRLNSVSLGNAVVEYRQDSERVLQLN
YRYATPEYIETALNTRQVPAYQDGISQVGVTGSWPIADRWAVVGAYYYDTRAQQSADQLL
GLKYNTCCWAVTLGYERKITDWNNSNNTSVYDNKVSFNIELRGLSSDHSLGSAEMLRSGI
LPYQRAF