Protein Info for IAI46_03255 in Serratia liquefaciens MT49

Annotation: peptidylprolyl isomerase SurA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF13624: SurA_N_3" amino acids 17 to 141 (125 residues), 54 bits, see alignment E=5.6e-18 PF13623: SurA_N_2" amino acids 25 to 105 (81 residues), 32.2 bits, see alignment E=2.9e-11 PF09312: SurA_N" amino acids 25 to 142 (118 residues), 156.8 bits, see alignment E=7.6e-50 PF13616: Rotamase_3" amino acids 166 to 273 (108 residues), 67.4 bits, see alignment E=5e-22 amino acids 281 to 383 (103 residues), 85.9 bits, see alignment E=9.3e-28 PF00639: Rotamase" amino acids 178 to 272 (95 residues), 73.1 bits, see alignment E=9.2e-24 amino acids 289 to 380 (92 residues), 83.1 bits, see alignment E=6.8e-27 PF13145: Rotamase_2" amino acids 189 to 277 (89 residues), 28.2 bits, see alignment E=8.4e-10 amino acids 296 to 385 (90 residues), 34.8 bits, see alignment E=7.9e-12

Best Hits

Swiss-Prot: 80% identical to SURA_YERPN: Chaperone SurA (surA) from Yersinia pestis bv. Antiqua (strain Nepal516)

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 99% identity to spe:Spro_0726)

MetaCyc: 74% identical to chaperone SurA (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (432 amino acids)

>IAI46_03255 peptidylprolyl isomerase SurA (Serratia liquefaciens MT49)
MKNWRTLILGLVVCANTAFAAPQEVDKVAAVVDNGVVLESDVNTLLQSVKLNAQQAGQQL
PDDKTLRHQILERLIMDNIQLQMAKKMGINVSDADLDKAIGNIAAQNKMSIDQMRSRLAY
EGLNYNTYRSQIRKEMLISEVRNNEVRRRVTILPQEVDSLATQVGAQNGSDTEMNISHIL
IPLPENPTQAQVDDAEALAKQLMGEINGGADFGKLAISYSADSQALKGGNMGWGKLQEIP
TLFAERLVNAKKGDVVGPIRSGVGFHILKVNDIRGANQSVSVTEVHARHILLKPSVVLTD
DQARAKLQAVAEAIKSGRAKFADEAKQLSQDPGSALQGGDLGWASPDIYDPAFRDALMKL
SKGEVSQPVHSSFGWHLIQLLDTRQVDKTDAAQKDRAYRMLFNRKFAEEAQTWMQEQRAQ
AYVKILDGNAQQ