Protein Info for IAI46_03040 in Serratia liquefaciens MT49

Annotation: threonine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF14821: Thr_synth_N
  • amino acids 8 to 80 (73 residues), 42.5 bits, E=5.8e-15
• TIGR00260: threonine synthase
  • amino acids 52 to 397 (346 residues), 411.2 bits, E=1.7e-127
• PF00291: PALP
  • amino acids 96 to 369 (274 residues), 91.5 bits, E=6.3e-30

Best Hits

Swiss-Prot: 95% identical to THRC_SERMA: Threonine synthase (thrC) from Serratia marcescens

KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 98% identity to spe:Spro_0685)

MetaCyc: 84% identical to threonine synthase (Escherichia coli K-12 substr. MG1655)
Threonine synthase. [EC: 4.2.3.1]

Predicted SEED Role

"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)

MetaCyc Pathways

• aspartate superpathway (25/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• L-threonine biosynthesis (2/2 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Vitamin B6 metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.1

Protein Sequence (429 amino acids)

>IAI46_03040 threonine synthase (Serratia liquefaciens MT49)
MKLYNLKDHNEQVSFAQAIKQGLGKQQGLFFPLELPEFELTEIDHLLEQDFVTRSSRILS
AFIGDEVSEEALHKRVAAAFEFPAPVAQVEDDIACLELFHGPTLAFKDFGGRFMAQMLAE
VAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPQGKISPLQEKLFCTLGGNIHTV
AIDGDFDACQALVKQAFDDQELKEALHLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLTNGQWQPHATVATLSNA
MDVSQPNNWPRVEELFRRKIWQLKELGHATVSDETTKDSMRELAQLGYLSEPHAAIAYRA
LRDQLKEGEFGLFLGTAHPAKFKESVEEILGQELPLPKALALRADLPLLSHNLPASFGEL
RKFLMALPA