Protein Info for IAI46_03000 in Serratia liquefaciens MT49

Annotation: 2,3-diphosphoglycerate-dependent phosphoglycerate mutase GpmB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00300: His_Phos_1
  • amino acids 4 to 194 (191 residues), 188.2 bits, E=6.7e-60

Best Hits

Swiss-Prot: 97% identical to GPMB_SERP5: Probable phosphoglycerate mutase GpmB (gpmB) from Serratia proteamaculans (strain 568)

KEGG orthology group: None (inferred from 96% identity to srr:SerAS9_0618)

Predicted SEED Role

"Phosphoglycerate mutase (EC 5.4.2.1)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 5.4.2.1)

MetaCyc Pathways

• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (25/26 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (17/17 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (18/19 steps found)
• superpathway of glucose and xylose degradation (16/17 steps found)
• gluconeogenesis I (13/13 steps found)
• glycolysis I (from glucose 6-phosphate) (13/13 steps found)
• superpathway of anaerobic sucrose degradation (17/19 steps found)
• glycolysis II (from fructose 6-phosphate) (11/11 steps found)
• glycolysis III (from glucose) (11/11 steps found)
• superpathway of hexitol degradation (bacteria) (16/18 steps found)
• homolactic fermentation (11/12 steps found)
• superpathway of N-acetylneuraminate degradation (18/22 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (18/22 steps found)
• Rubisco shunt (9/10 steps found)
• Bifidobacterium shunt (12/15 steps found)
• glycolysis IV (8/10 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (19/26 steps found)
• glycolysis VI (from fructose) (8/11 steps found)
• ethene biosynthesis V (engineered) (18/25 steps found)
• glycolysis V (Pyrococcus) (7/10 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (19/27 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
• glycerol degradation to butanol (11/16 steps found)
• photorespiration II (6/10 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (9/18 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (22/56 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Glycolysis / Gluconeogenesis

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.1

Use Curated BLAST to search for 5.4.2.1

Protein Sequence (215 amino acids)

>IAI46_03000 2,3-diphosphoglycerate-dependent phosphoglycerate mutase GpmB (Serratia liquefaciens MT49)
MLQVYLVRHGETEWNAARRIQGQSDSPLTAHGEHQAHLVAQRVSKLGITHVITSDLGRTR
RTAQIIAEACGCEVINDPRLRELHMGVLEERLIDSLTPQEEQWRKQMVDGTADGRIPQGE
SMSELGGRMREALESCLMLPEGSKPLIVSHGIALGCLISTVLGLPAYAERRLRLRNCSLS
RVDYQQSPWLASGWIVETAGDITHLDMPALDELQR