Protein Info for IAI46_02990 in Serratia liquefaciens MT49

Annotation: trp operon repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 109 TIGR01321: trp operon repressor" amino acids 12 to 104 (93 residues), 124.1 bits, see alignment E=1.2e-40 PF01371: Trp_repressor" amino acids 18 to 103 (86 residues), 103.6 bits, see alignment E=2.6e-34

Best Hits

Swiss-Prot: 98% identical to TRPR_SERP5: Trp operon repressor (trpR) from Serratia proteamaculans (strain 568)

KEGG orthology group: K03720, TrpR family transcriptional regulator, trp operon repressor (inferred from 97% identity to srs:SerAS12_0616)

Predicted SEED Role

"Transcriptional repressor protein TrpR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (109 amino acids)

>IAI46_02990 trp operon repressor (Serratia liquefaciens MT49)
MTQLSLNDPALSEQGNEDWLRFVALLQNSFAQDLHQPLLQLLLTPDERTALGTRVRIIQE
LMRGEMSQRELKNELGAGIATITRGSNSLKAATPALKQWLEQQLLGEAP