Protein Info for IAI46_02800 in Serratia liquefaciens MT49
Annotation: L-fuconate dehydratase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 59% identical to ENOF1_XENLA: Mitochondrial enolase superfamily member 1 (enosf1) from Xenopus laevis
KEGG orthology group: None (inferred from 97% identity to spe:Spro_0640)MetaCyc: 60% identical to L-galactonate dehydratase (Trichoderma reesei)
RXN-11380 [EC: 4.2.1.146]
Predicted SEED Role
"L-fuconate dehydratase (EC 4.2.1.68)" in subsystem L-fucose utilization temp (EC 4.2.1.68)
MetaCyc Pathways
- L-fucose degradation III (8/8 steps found)
- L-fucose degradation II (4/5 steps found)
- D-galacturonate degradation IV (2/5 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (14/31 steps found)
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.2.1.146 or 4.2.1.68
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (425 amino acids)
>IAI46_02800 L-fuconate dehydratase (Serratia liquefaciens MT49) MTTITALRVEDIRFPTSLALDGSDAMNPDPDYSAAYVILETDRADLSGHGLTFTIGRGNE ICCAAIRALEHQIVGVTLEEIAADMGAFWRRFTSDSQLRWIGPDKGAIHLATGAVINAVW DLWAKAEGKPVWRLVAEMTPEELVRCIDFRYITDCITPQEALTLLKQRAQGKEQRLERLL EDGYPCYTTSAGWLGYPDDKLRRLCQEAVDAGFSYLKLKVGRDLEDDIRRVRIAREVIGP DRQLMIDANQVWEVNDAIPWVKHLAFAKPWFIEEPTSPDDVEGHRRIREGVHPVKVATGE MCQNRIMFKQFIMREAIDVVQIDACRLGGVNEVLAVMLMAAKYNLPVCPHAGGVGLCEYV QHLSMIDYLCIAGTHEGRVIEYVDHLHEHFVHPCDVKGAAYMPPRHPGYSIEMHASSLEQ YRFRG