Protein Info for IAI46_02765 in Serratia liquefaciens MT49

Annotation: 4-hydroxyphenylacetate catabolism regulatory protein HpaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 302 TIGR02297: 4-hydroxyphenylacetate catabolism regulatory protein HpaA" amino acids 12 to 296 (285 residues), 410.1 bits, see alignment E=2.3e-127 PF02311: AraC_binding" amino acids 45 to 117 (73 residues), 27.3 bits, see alignment E=2.7e-10 PF12833: HTH_18" amino acids 218 to 296 (79 residues), 72.1 bits, see alignment E=4e-24

Best Hits

KEGG orthology group: K02508, AraC family transcriptional regulator, 4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein (inferred from 96% identity to srs:SerAS12_0569)

Predicted SEED Role

"Transcriptional activator of 4-hydroxyphenylacetate 3-monooxygenase operon, XylS/AraC family" in subsystem 4-Hydroxyphenylacetic acid catabolic pathway

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (302 amino acids)

>IAI46_02765 4-hydroxyphenylacetate catabolism regulatory protein HpaA (Serratia liquefaciens MT49)
MEDDVQKSTGFIANIDICKEYDARYATDEVHYETFAGLAAFFGRDMQVHWHDRFFQMHFL
ETGKIELQLDSQHYSVQAPLFILTPPSVPHAFFTEPDSDGHVLTVRQELIWPLLERLYPG
SNLALDMPGICLSLADAPQELTALSHYWALIRREFSQRLVGREQTLVLLAQAVFTLLLRN
TTLEDTATSGVRGELKLFQRFNKMVDERFRDHLAVPDYAQALGVTESRLNDLCRRFANQP
PKRLIFDRLLREAKRMLLFSACTVHETAYSLGFKDPAYFARFFNRLEGCSPSTYRAAQHP
LS