Protein Info for IAI46_02760 in Serratia liquefaciens MT49

Annotation: 4-hydroxyphenylacetate permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 transmembrane" amino acids 34 to 57 (24 residues), see Phobius details amino acids 68 to 88 (21 residues), see Phobius details amino acids 100 to 119 (20 residues), see Phobius details amino acids 125 to 148 (24 residues), see Phobius details amino acids 160 to 182 (23 residues), see Phobius details amino acids 194 to 214 (21 residues), see Phobius details amino acids 265 to 289 (25 residues), see Phobius details amino acids 303 to 324 (22 residues), see Phobius details amino acids 342 to 365 (24 residues), see Phobius details amino acids 378 to 400 (23 residues), see Phobius details amino acids 410 to 430 (21 residues), see Phobius details TIGR02332: 4-hydroxyphenylacetate permease" amino acids 26 to 421 (396 residues), 768.6 bits, see alignment E=8.7e-236 PF07690: MFS_1" amino acids 38 to 361 (324 residues), 149.5 bits, see alignment E=1.3e-47 PF00083: Sugar_tr" amino acids 66 to 326 (261 residues), 22.8 bits, see alignment E=4.1e-09

Best Hits

KEGG orthology group: K02511, MFS transporter, ACS family, 4-hydroxyphenylacetate permease (inferred from 92% identity to spe:Spro_0632)

Predicted SEED Role

"4-hydroxyphenylacetate symporter, major facilitator superfamily (MFS)" in subsystem 4-Hydroxyphenylacetic acid catabolic pathway

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (440 amino acids)

>IAI46_02760 4-hydroxyphenylacetate permease (Serratia liquefaciens MT49)
MSNVDSLPPVNPAQQHKALTAAEQSVIKKLFRRLIIFLFVLFVFSFLDRINIGFAGLTMG
KDLGLSSTMFGLAATLFYVTYVIFGIPSNIMLGIVGARRWIATIMVLWGIASTCTLFATG
PTSLYLLRMIVGITEAGFLPGILVYLTYWFPAFYRARANALFMIAMPVTMAIGSLVSGYI
LALDGLMNLKGWQWLFLLEGIPSVLLGVVVWFYLDDTPAKAKWLTDEEKASLKAMMEADK
LQLVQPNGPGSHRALQQRSLWREIFTPIVLMYTLAYFCLTNTLSAINIWTPQILQSFNQS
SSNIVIGILAAIPQVCTIAGMVWWSKRSDRLQERKHHTALPYLFAAAGWLLASVGSFTAM
AIFWTTPDQSISLEARAIGIAVINATGNIGSAVSPVLIGWFKDLTGSFNSGLYFVSALLV
IGAVIVWRIPMQGSRPRATP