Protein Info for IAI46_02335 in Serratia liquefaciens MT49

Annotation: GMC family oxidoreductase N-terminal domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 535 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details PF00732: GMC_oxred_N" amino acids 6 to 295 (290 residues), 191.8 bits, see alignment E=2.2e-60 PF05199: GMC_oxred_C" amino acids 388 to 526 (139 residues), 127 bits, see alignment E=1.2e-40

Best Hits

KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 97% identity to spe:Spro_0557)

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (535 amino acids)

>IAI46_02335 GMC family oxidoreductase N-terminal domain-containing protein (Serratia liquefaciens MT49)
MSENAFDYIIVGAGSAGCVLAAQLIRRTQARVLLLEAGGDDNNLFIKMPAGVAKIIAKKS
WPYETEPEPHANNRRMQIAQGKVLGGSSSVNGMIYIRGQRQDYDEWAERYGCVGWGYQDV
LPYFKRAEANESLSDAYHGGEGLLPVSENRYRHPLSMAFIRAGQELNLPYRNDFNGDSQH
GVGFYQTTTHNGERASTARSYLKAVRNDQRLVVKLNALVHRVVLDNNVATGVVYSQNGGA
EVTAHAAKEVILSAGAVGSPKILMLSGIGPREHLQQLGITPLADLPVGKNFHDHLHMSIN
VSTRQPISLYGADRGLQALRHGTEWLAFRSGVLSSNVLEGAAFTDSQGDGRPDVQIHFLP
MLDSWDDVPGEPLPNIHGFTLKVGYLQPKARGEVLLRSRDPRDPVKLHANYLGHPEDLAG
SVRAVKFGLRFLQTAALKPLIKDLLMPQPAWLNDDAQLEEFVRNFCKTVYHPVGSCRMGQ
SPQDSVTDLQLQVHGFERLRVIDCSVMPQVTSGNTNAPTIMLAEKAVDLLLGAPA