Protein Info for IAI46_02220 in Serratia liquefaciens MT49

Annotation: HTH-type transcriptional regulator TreR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 TIGR02405: trehalose operon repressor" amino acids 4 to 314 (311 residues), 509.6 bits, see alignment E=1.7e-157 PF00356: LacI" amino acids 6 to 51 (46 residues), 73.3 bits, see alignment 1.6e-24 PF00532: Peripla_BP_1" amino acids 64 to 254 (191 residues), 58.5 bits, see alignment E=1.1e-19 PF13377: Peripla_BP_3" amino acids 168 to 304 (137 residues), 59.5 bits, see alignment E=7e-20

Best Hits

Swiss-Prot: 63% identical to TRER_SALTY: HTH-type transcriptional regulator TreR (treR) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03485, LacI family transcriptional regulator, trehalose operon repressor (inferred from 95% identity to spe:Spro_0534)

Predicted SEED Role

"Trehalose operon transcriptional repressor" in subsystem Trehalose Uptake and Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (315 amino acids)

>IAI46_02220 HTH-type transcriptional regulator TreR (Serratia liquefaciens MT49)
MQNRLTIKDIARLSGVGKSTVSRVLNNEGSVSPQTRERVEAVIRQQGFTPSKSARAMRGQ
SDKVVGIIVSRLDSPSENQAVRTMLPLLYQHGFDPIVMESQFETRLVEEHLHVLQQRNVD
GVILFGFTGLTAAMLSPWQEKMVVLAREYDGFSSVCYDDDGAVRLLMERLHQQGHRHISY
LGVQLSDATTGLRRHQAYLDACRQRGISPHVALGELSYQSGFQLAASAIEPQTTALVCAS
DTIALGAIKYLQQQHITPLQVCGIGNTPLLNFLFPETFSVDLGYGSAGLQAAQQLLGQLS
GEQGLRQIIVPSKLA