Protein Info for IAI46_01935 in Serratia liquefaciens MT49

Annotation: translation initiation factor IF-2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 895 PF04760: IF2_N" amino acids 3 to 53 (51 residues), 38.9 bits, see alignment 2.4e-13 amino acids 319 to 369 (51 residues), 60.1 bits, see alignment 5.6e-20 PF08364: IF2_assoc" amino acids 58 to 96 (39 residues), 62.7 bits, see alignment (E = 1.1e-20) TIGR00487: translation initiation factor IF-2" amino acids 311 to 894 (584 residues), 978.6 bits, see alignment E=1.3e-298 TIGR00231: small GTP-binding protein domain" amino acids 398 to 553 (156 residues), 113.1 bits, see alignment E=1.1e-36 PF00009: GTP_EFTU" amino acids 398 to 554 (157 residues), 127.8 bits, see alignment E=1.6e-40 PF01926: MMR_HSR1" amino acids 399 to 504 (106 residues), 40.5 bits, see alignment E=1.1e-13 PF00071: Ras" amino acids 400 to 554 (155 residues), 24.3 bits, see alignment E=8.2e-09 PF00025: Arf" amino acids 401 to 553 (153 residues), 22.9 bits, see alignment E=2.1e-08 PF11987: IF-2" amino acids 670 to 784 (115 residues), 144.5 bits, see alignment E=5.3e-46 PF03144: GTP_EFTU_D2" amino acids 815 to 882 (68 residues), 35.4 bits, see alignment 4.8e-12

Best Hits

Swiss-Prot: 86% identical to IF2_ECO81: Translation initiation factor IF-2 (infB) from Escherichia coli O81 (strain ED1a)

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 88% identity to ddc:Dd586_0600)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (895 amino acids)

>IAI46_01935 translation initiation factor IF-2 (Serratia liquefaciens MT49)
MTTDVTVKSLAAEIQTPVDRLVQQFADAGINKSETDSVTQHEKEALLAHLNREHGSAPGK
LTLQRKTRSTLNIPSTGGKSKSVQIEVRKKRTYVNRDTPEAQQAEAAEQAQREAEEQAQR
EAEELAKREAEAKRAAEEQAKREAAEIAKRNSAEKEKVTNQHTDEMTKPAQAEKARREAE
AAELKRKAEEEVRRKVEEDAKRVAEEARRMAEENGEKWAEAEAASAAVETADYHVTTSQH
ARAAEDENDAKVEGERRSRTRGGKATKQKKGNKLSESKADREEARAVTRGGKGKRKPSTL
QQGFNKPAQVVNRDVIIGETITVAELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQ
LVAEEMGHKVILRRENELEEALMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTK
VAAGEAGGITQHIGAYHVETDNGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGV
MPQTIEAIQHAKAAQVPLVVAVNKIDKPEADPDRVKQELSQYGVMPEEWGGEAQFVHVSA
KAGTGIDELLNAILLQSEVLELKAVRSGMASGVVIESFLDKGRGPVATVLVQEGTLNKGD
IVLCGFEYGRVRAMRDELGREVTSAGPSIPVEILGLSSVPAAGDEATVVRDEKKAREVAL
YRQGKFREVKLARQQKSKLENMFANMTDGEVSELNIVLKSDVQGSCEAIMDSLLKLSTDE
VKVKIVGSGVGGITETDATLAAASNAIILGFNVRADASARRVIEAESLDLRYYSVIYNLI
DEVKQAMSGMLAPEYKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGNIKRHNPIRVLRDNV
VIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRVGDMIEVFEIIEIQRTIA