Protein Info for IAI46_01905 in Serratia liquefaciens MT49

Annotation: phosphoglucosamine mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 4 to 135 (132 residues), 157.3 bits, E=3.8e-50
• TIGR01455: phosphoglucosamine mutase
  • amino acids 7 to 442 (436 residues), 654.4 bits, E=3.9e-201
• PF02879: PGM_PMM_II
  • amino acids 157 to 254 (98 residues), 67.8 bits, E=2.3e-22
• PF02880: PGM_PMM_III
  • amino acids 258 to 365 (108 residues), 118.2 bits, E=4.1e-38
• PF00408: PGM_PMM_IV
  • amino acids 373 to 442 (70 residues), 65.2 bits, E=9.5e-22

Best Hits

Swiss-Prot: 98% identical to GLMM_SERP5: Phosphoglucosamine mutase (glmM) from Serratia proteamaculans (strain 568)

KEGG orthology group: K03431, phosphoglucosamine mutase [EC: 5.4.2.10] (inferred from 98% identity to spe:Spro_0485)

MetaCyc: 86% identical to phosphoglucosamine mutase (Escherichia coli K-12 substr. MG1655)
Phosphoglucosamine mutase. [EC: 5.4.2.10]

Predicted SEED Role

"Phosphoglucosamine mutase (EC 5.4.2.10)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 5.4.2.10)

MetaCyc Pathways

• superpathway of anaerobic sucrose degradation (17/19 steps found)
• peptidoglycan recycling I (13/14 steps found)
• D-galactose degradation I (Leloir pathway) (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• glucose and glucose-1-phosphate degradation (5/5 steps found)
• glycogen degradation I (7/8 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (4/4 steps found)
• O-antigen building blocks biosynthesis (E. coli) (9/11 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (5/6 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• sucrose biosynthesis II (6/8 steps found)
• starch degradation V (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• colanic acid building blocks biosynthesis (8/11 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• glycogen degradation II (4/6 steps found)
• dTDP-β-L-rhamnose biosynthesis (3/5 steps found)
• glucosylglycerol biosynthesis (3/5 steps found)
• starch degradation III (2/4 steps found)
• starch biosynthesis (6/10 steps found)
• chitin biosynthesis (5/9 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (2/8 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
• streptomycin biosynthesis (2/18 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.2.10

Protein Sequence (445 amino acids)

>IAI46_01905 phosphoglucosamine mutase (Serratia liquefaciens MT49)
MSERKYFGTDGIRGKVGESPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLES
ALEAGLAAAGLSASFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGAK
LPDHVEEAIEAEMEKPLTCVESSELGKASRIIDAAGRYIEFCKGTFPSELSLKGLKIVVD
CANGATYHIAPSVLRELGATVIAIGVEPDGMNINEKCGATDVRQLQERVLQEKAHVGLAF
DGDGDRVMMVDHLGHKVDGDQILYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIP
FARAKVGDRYVLEKLQELGWRIGAENSGHVILLDKTTTGDGIVAGLQVLTAMVRNNMSLH
DLCSGMKLLPQILVNVRFVGEHNPLESEEVRKITEQVEAELAGRGRVLLRKSGTEPLIRV
MVEGEDEQQVTALAHRIADAVKSAG