Protein Info for IAI46_01615 in Serratia liquefaciens MT49

Annotation: DNA mismatch repair endonuclease MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 624 TIGR00585: DNA mismatch repair protein MutL" amino acids 1 to 310 (310 residues), 334.7 bits, see alignment E=3.8e-104 PF02518: HATPase_c" amino acids 21 to 77 (57 residues), 32.5 bits, see alignment 2e-11 PF13589: HATPase_c_3" amino acids 24 to 120 (97 residues), 49.2 bits, see alignment E=1.1e-16 PF01119: DNA_mis_repair" amino acids 214 to 329 (116 residues), 134.6 bits, see alignment E=2.7e-43 PF08676: MutL_C" amino acids 453 to 577 (125 residues), 95.3 bits, see alignment E=5.9e-31

Best Hits

Swiss-Prot: 93% identical to MUTL_SERP5: DNA mismatch repair protein MutL (mutL) from Serratia proteamaculans (strain 568)

KEGG orthology group: None (inferred from 93% identity to srr:SerAS9_0368)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (624 amino acids)

>IAI46_01615 DNA mismatch repair endonuclease MutL (Serratia liquefaciens MT49)
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CGIGKDDLALALARHATSKISTLDDLEAIVSLGFRGEALASISSVSRLTLTSRTAEQNEA
WQAYAEGRDQAVTLKPAAHPIGSTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIAL
ARFDVAINLSHNGKLIRQYRAAKDESHYERRLGSICGPAFLQHALNISWQHGDLTIRGWV
ADPAGARQLGEMQYCYVNSRMMRDRLINHAIRQAYQDQLKDDQQPAYVLYLEVDPHQVDV
NVHPAKHEVRFHQARLVHDFIYQAVTTVLQQVGNAPLPLDDEPEQPSAPTWQPENRVAAG
GNHFSQPAPRREPQPSEPGVARERAPQPAYQAGNGYQKREGELYGKLMQAAPVVEPAPET
PKQPLFPPVKAEREVPLDGSQHSFGRVLMIHPPCFALIERRQQLMLLNLPVAERWLRQAQ
LNPAEEGLRPQPLLIPIKLMLNKQEAAACVRHQPLLVKMGLDLQADHGRVTLRAVPLPLR
QQNLQKLIPELLGYLAEHQEMSPPVLATWFARHLGSEHEQWNTSQAIQLLTDVERLCPQL
VKSPPSGLLQPVDLQAALAALTHD