Protein Info for IAI46_01360 in Serratia liquefaciens MT49

Annotation: phosphoribosylamine--glycine ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00877: phosphoribosylamine--glycine ligase
  • amino acids 1 to 423 (423 residues), 606.4 bits, E=1.4e-186
• PF02844: GARS_N
  • amino acids 1 to 102 (102 residues), 130.6 bits, E=8.5e-42
• PF01071: GARS_A
  • amino acids 103 to 296 (194 residues), 283.2 bits, E=2.8e-88
• PF02655: ATP-grasp_3
  • amino acids 105 to 292 (188 residues), 26 bits, E=2.2e-09
• PF02786: CPSase_L_D2
  • amino acids 112 to 290 (179 residues), 28.5 bits, E=2.6e-10
• PF02843: GARS_C
  • amino acids 331 to 421 (91 residues), 113.3 bits, E=1.3e-36

Best Hits

Swiss-Prot: 88% identical to PUR2_YERPE: Phosphoribosylamine--glycine ligase (purD) from Yersinia pestis

KEGG orthology group: K01945, phosphoribosylamine--glycine ligase [EC: 6.3.4.13] (inferred from 96% identity to spe:Spro_0292)

MetaCyc: 80% identical to phosphoribosylamine--glycine ligase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylamine--glycine ligase. [EC: 6.3.4.13]

Predicted SEED Role

"Phosphoribosylamine--glycine ligase (EC 6.3.4.13)" in subsystem De Novo Purine Biosynthesis (EC 6.3.4.13)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (26/26 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.13

Protein Sequence (427 amino acids)

>IAI46_01360 phosphoribosylamine--glycine ligase (Serratia liquefaciens MT49)
MNILIIGNGGREHALAWKAAQSPLADKVYVAPGNAGTALEPGLTNVEISATDIPALLTFA
QSNDIGLTIVGPEAPLVIGVVDAFQAASLKIFGPSQAAAQLEGSKAFTKDFLARHNIPSA
EYQNFTEVEPALAYVRSKGAPIVIKADGLAAGKGVIVAMTLQEAEDAVQDMLAGNAFGDA
GHRIVVEEFLDGEEASFIVMVDGENVVPMATSQDHKRVGDGDTGPNTGGMGAYSPAPVVT
DEIHQRAMDQVIWPTVRGMAAEGNTYVGFLYAGLMISADGQPKVIEFNCRFGDPETQPIM
LRLRSDLVELCLAGAEGKLDEKTSEWDERPALGVVLAAGGYPGDYNNGEVIQGLPQQESA
DGKVFHAGTRMQGNDVVTSGGRVLCVTALGETVAQAQQRAYQLADGIQWTGSFCRKDIGY
RAIARGK