Protein Info for IAI46_01335 in Serratia liquefaciens MT49

Annotation: uroporphyrinogen decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01208: URO-D
  • amino acids 5 to 347 (343 residues), 485.3 bits, E=5e-150
• TIGR01464: uroporphyrinogen decarboxylase
  • amino acids 9 to 346 (338 residues), 454.9 bits, E=7.5e-141

Best Hits

Swiss-Prot: 99% identical to DCUP_SERP5: Uroporphyrinogen decarboxylase (hemE) from Serratia proteamaculans (strain 568)

KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 99% identity to spe:Spro_0287)

MetaCyc: 90% identical to uroporphyrinogen decarboxylase (Escherichia coli K-12 substr. MG1655)
Uroporphyrinogen decarboxylase. [EC: 4.1.1.37]

Predicted SEED Role

"Uroporphyrinogen III decarboxylase (EC 4.1.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.1.1.37)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glutamate (10/10 steps found)
• superpathway of heme b biosynthesis from glycine (8/8 steps found)
• superpathway of heme b biosynthesis from uroporphyrinogen-III (6/6 steps found)
• heme b biosynthesis I (aerobic) (4/4 steps found)
• heme b biosynthesis II (oxygen-independent) (4/4 steps found)
• heme b biosynthesis V (aerobic) (4/4 steps found)
• heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (3/9 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (7/26 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.37

Protein Sequence (354 amino acids)

>IAI46_01335 uroporphyrinogen decarboxylase (Serratia liquefaciens MT49)
MNELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
LQPLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPRFSSPITCRADVDKLPAFDPEVE
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKLKKMMYAEPATLHL
LLDKLADSVILYLNAQIKAGAQSVMVFDTWGGVLTGRDYREFSLHYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSMLYAS
PERIAQEVETILAGFGHGEGHVFNLGHGIHLDVPPENAGAFVEAVHAQSGKYHR