Protein Info for IAI46_01190 in Serratia liquefaciens MT49

Annotation: type I pantothenate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00554: pantothenate kinase
  • amino acids 10 to 316 (307 residues), 552 bits, E=1.9e-170
• PF00485: PRK
  • amino acids 90 to 244 (155 residues), 55.3 bits, E=4e-19

Best Hits

Swiss-Prot: 99% identical to COAA_SERP5: Pantothenate kinase (coaA) from Serratia proteamaculans (strain 568)

KEGG orthology group: K00867, type I pantothenate kinase [EC: 2.7.1.33] (inferred from 99% identity to spe:Spro_0269)

MetaCyc: 83% identical to pantothenate kinase (Escherichia coli K-12 substr. MG1655)
Pantetheine kinase. [EC: 2.7.1.34]; Pantothenate kinase. [EC: 2.7.1.34, 2.7.1.33]

Predicted SEED Role

"Pantothenate kinase (EC 2.7.1.33)" in subsystem Coenzyme A Biosynthesis (EC 2.7.1.33)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• phosphopantothenate biosynthesis I (4/4 steps found)
• phosphopantothenate biosynthesis II (1/3 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (6/10 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.33 or 2.7.1.34

Protein Sequence (316 amino acids)

>IAI46_01190 type I pantothenate kinase (Serratia liquefaciens MT49)
MIKRDQSLATPYLQFDRTQWAALRDSVPLTLSEEEIVKLKGINEDLSLEEVAQIYLPLSR
LLNFYISSNLRRQAVLEQFLGTDGQKIPYVIGIAGSVAVGKSTTARLLQALLSSWPEHRS
VELITTDGFLHPNKVLNERGLMKKKGFPQSYDMHSLVKFVSEVKSGAKRVTAPVYSHLIY
DVVPEGNKVIEQPDILILEGLNVLQSGMDYPHDPHRVFVSDFVDFSIYVDAPEELLQSWY
INRFLKFRQGAFSNPDSYFHNYSKLPEPEAVNIATQLWNEINGLNLQENILPTRERASLI
MTKSANHAVESVRLRK