Protein Info for IAI46_01045 in Serratia liquefaciens MT49

Annotation: uridine phosphorylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01718: uridine phosphorylase
  • amino acids 6 to 253 (248 residues), 408.4 bits, E=4.7e-127
• PF01048: PNP_UDP_1
  • amino acids 21 to 242 (222 residues), 132.6 bits, E=7.5e-43

Best Hits

Swiss-Prot: 92% identical to UDP_SALTI: Uridine phosphorylase (udp) from Salmonella typhi

KEGG orthology group: K00757, uridine phosphorylase [EC: 2.4.2.3] (inferred from 98% identity to srs:SerAS12_0200)

MetaCyc: 90% identical to uridine phosphorylase (Escherichia coli K-12 substr. MG1655)
Pyrimidine-nucleoside phosphorylase. [EC: 2.4.2.2, 2.4.2.3]

Predicted SEED Role

"Uridine phosphorylase (EC 2.4.2.3)" (EC 2.4.2.3)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleosides degradation (6/6 steps found)
• pyrimidine deoxyribonucleosides degradation (3/3 steps found)
• pyrimidine ribonucleosides degradation (2/2 steps found)
• superpathway of pyrimidine ribonucleosides degradation (3/5 steps found)
• nucleoside and nucleotide degradation (archaea) (4/10 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.2

Use Curated BLAST to search for 2.4.2.2 or 2.4.2.3

Protein Sequence (253 amino acids)

>IAI46_01045 uridine phosphorylase (Serratia liquefaciens MT49)
MSQSDVFHLGLTKNDLQGAQLAIVPGDPQRVEKIAKLMENPVHLASHREFTSWRAELDGK
AVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQSDINVGDVLVTTAAVRLDGAS
LHFAPMEFPAVADFACTTALVEAAKAAGATTHIGVTASSDTFYPGQERYDTFSGRVVSRF
KGSMEEWQSMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKNTESK
AVQIVVDAARRLL