Protein Info for IAI46_00765 in Serratia liquefaciens MT49

Annotation: phospholipase A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02253: PLA1
  • amino acids 43 to 288 (246 residues), 313.6 bits, E=5.8e-98

Best Hits

Swiss-Prot: 74% identical to PA1_ECOLI: Phospholipase A1 (pldA) from Escherichia coli (strain K12)

KEGG orthology group: K01058, phospholipase A1 [EC: 3.1.1.32] (inferred from 96% identity to spe:Spro_0192)

MetaCyc: 74% identical to outer membrane phospholipase A (Escherichia coli K-12 substr. MG1655)
Lysophospholipase. [EC: 3.1.1.5]; 3.1.1.5 [EC: 3.1.1.5]; Phospholipase A(2). [EC: 3.1.1.5, 3.1.1.4]; Phospholipase A(1). [EC: 3.1.1.5, 3.1.1.4, 3.1.1.32]

Predicted SEED Role

"Phospholipase A1 precursor (EC 3.1.1.32, EC 3.1.1.4); Outer membrane phospholipase A"

MetaCyc Pathways

• phospholipid remodeling (phosphatidate, yeast) (1/2 steps found)
• phosphatidylcholine acyl editing (2/4 steps found)
• phospholipid remodeling (phosphatidylethanolamine, yeast) (2/4 steps found)
• phospholipases (2/5 steps found)
• anandamide biosynthesis II (2/8 steps found)
• plasmalogen degradation (2/8 steps found)
• anandamide biosynthesis I (4/12 steps found)
• peptido-conjugates in tissue regeneration biosynthesis (3/17 steps found)

KEGG Metabolic Maps

• Arachidonic acid metabolism
• Ether lipid metabolism
• Glycerophospholipid metabolism
• Linoleic acid metabolism
• alpha-Linolenic acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.32, 3.1.1.5

Use Curated BLAST to search for 3.1.1.32 or 3.1.1.4 or 3.1.1.5

Protein Sequence (292 amino acids)

>IAI46_00765 phospholipase A (Serratia liquefaciens MT49)
MRILSGIVLATLAAPLLVQAEEAKEQQIHDKPAVRGSIIANMLQDHDNPFTLYPYETNYV
LYTDTSNINKEAIQSYNWSDNARKDEVKFQLSLAFPLWRGIAGDNSVLGASYTQRSWWQL
SNHGESSPFRETNYEPQVFLGWATDYRFAGWTLRDVEVGLNHQSNGRSDPTSRSWNRGYA
RFMAQNGNWQVDLKPWFRFSESSSSDDNPDITKYMGYYRLKVGYAWGDSIFSVDSHYNWN
SGYGGAEMGWSYPISKHVRFYTQVFSGYGESLIDYNFRQTRVGVGVMLNDIM