Protein Info for IAI46_00600 in Serratia liquefaciens MT49

Annotation: UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00236: UDP-N-acetylglucosamine 2-epimerase
  • amino acids 1 to 373 (373 residues), 566.8 bits, E=1.1e-174
• PF02350: Epimerase_2
  • amino acids 22 to 371 (350 residues), 422.2 bits, E=6.9e-131

Best Hits

Swiss-Prot: 88% identical to WECB_YERPE: UDP-N-acetylglucosamine 2-epimerase (wecB) from Yersinia pestis

KEGG orthology group: K01791, UDP-N-acetylglucosamine 2-epimerase [EC: 5.1.3.14] (inferred from 98% identity to spe:Spro_0163)

MetaCyc: 80% identical to UDP-N-acetylglucosamine 2-epimerase (Escherichia coli K-12 substr. MG1655)
UDP-N-acetylglucosamine 2-epimerase. [EC: 5.1.3.14]

Predicted SEED Role

"UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14)" in subsystem CMP-N-acetylneuraminate Biosynthesis or Sialic Acid Metabolism (EC 5.1.3.14)

MetaCyc Pathways

• CMP-N-acetylneuraminate biosynthesis II (bacteria) (3/3 steps found)
• UDP-N-acetyl-α-D-mannosamine biosynthesis (1/1 steps found)
• CMP-N-acetylneuraminate biosynthesis I (eukaryotes) (2/5 steps found)
• superpathway of CMP-sialic acids biosynthesis (4/15 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.14

Protein Sequence (377 amino acids)

>IAI46_00600 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) (Serratia liquefaciens MT49)
MKVLTVFGTRPEAIKMAPLVHALAQDEAFESRVCVTAQHREMLDQVLRLFEIVPDYDLNI
MKPGQGLSEITCRILEGLKGVLEEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGL
RTGDLYSPWPEEANRKLTGHLAMYHFAPTENSRQNLLRELLPDDHIFVTGNTVIDALFWV
RDRVMGDAALHDSLAQRYPFLDADNKKLILVTGHRRESFGGGFERICSALAEIARTHPEV
QVVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMAKSYMILTDSGGIQEEAPS
LGKPVLVMRDTTERPEAVDSGTVRLVGTDVAKIVDAVNRLLTDENEYHAMSRAHNPYGDG
HACQRILEALKNHQVTL