Protein Info for IAI46_00530 in Serratia liquefaciens MT49

Annotation: cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 767 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 732 to 750 (19 residues), see Phobius details PF03170: BcsB" amino acids 59 to 667 (609 residues), 742.1 bits, see alignment E=2.4e-227

Best Hits

Swiss-Prot: 61% identical to BCSB_SALTI: Cyclic di-GMP-binding protein (bcsB) from Salmonella typhi

KEGG orthology group: None (inferred from 96% identity to spe:Spro_0149)

MetaCyc: 63% identical to cellulose synthase periplasmic subunit (Escherichia coli K-12 substr. MG1655)
Cellulose synthase (UDP-forming). [EC: 2.4.1.12]

Predicted SEED Role

"Cyclic di-GMP binding protein precursor"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.12

Use Curated BLAST to search for 2.4.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (767 amino acids)

>IAI46_00530 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB (Serratia liquefaciens MT49)
MTRKITWFTALALGISTLSQAETATAPTGQPPVTIPADASVTTPMGSAAPVDPNAPVRDV
QLPFATIAPPPGTFTLRGTRPDGQVEFGVRSDEVVSQAMLDLEFTPSPSLIPVESHVKVY
LNDELMGVTTLAKEQLGKPNRIQMAIDPRYITDFNRVRLVFVGHYQNICENPASTTLWLE
VSKSSSLNLRFQTLPVKNELSHFPEPFFDSRDNRPLILPMVFAGQPDITQQRAAGILASW
FGSKAQWRGQSFPTLYNKLPEQHAIVFATNKQRPDFLRDYPAVNGPTVEMISHPDNPYIK
LLLVQGRDDNDLITAVKGIAQGNILFRGQNVTVDKVEQLAPRQPYDAPNWVRTDRPMTFA
ELQQYAEQLQTSGIEPGPISLTMNLPPDLFLIRSTGIDMHLKYRYTAPRIQDGSRLSVSL
NNQFVQAYSLVPEHEQGAQLLRLPLTQGLIDSDKNVNIPALRLGATNQLRFDFDYTTLLA
SGAEGRCETYSFTANHAVIDGASTIDFSGYRHFMAMPDLRAFANAGFPFSRLADLSQTLV
LVNKQPQPAQVSALLNAMGIIGAQTGYPALAMTLSDDWSQAKDRDADILMIGTIPPELKD
DKKISLLVDATQSWVKQPTRQLPLPTMDVLAEDTKPDSKTTISSEGAMAAIIGVQSPFNA
QRSIVALLADSARGYDLLNTAQLDSGKRAAVFGSVAVIRESGVNSLRVGDVYYVGHLPWW
ERIWHALSTHPVWLAVIAVVVVVVLALMLWRGLKAFSRRRLSPEDRD