Protein Info for IAI46_00095 in Serratia liquefaciens MT49
Annotation: sugar kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 54% identical to KDGK_BACSU: 2-dehydro-3-deoxygluconokinase (kdgK) from Bacillus subtilis (strain 168)
KEGG orthology group: K00874, 2-dehydro-3-deoxygluconokinase [EC: 2.7.1.45] (inferred from 95% identity to spe:Spro_0059)Predicted SEED Role
"2-ketogluconate kinase (EC 2.7.1.13)" in subsystem 2-Ketogluconate Utilization (EC 2.7.1.13)
MetaCyc Pathways
- glucose degradation (oxidative) (5/5 steps found)
- D-fructuronate degradation (4/4 steps found)
- superpathway of β-D-glucuronosides degradation (6/7 steps found)
- superpathway of hexuronide and hexuronate degradation (8/10 steps found)
- D-galacturonate degradation I (4/5 steps found)
- Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
- 4-deoxy-L-threo-hex-4-enopyranuronate degradation (2/5 steps found)
- 3,6-anhydro-α-L-galactopyranose degradation (3/7 steps found)
- alginate degradation (1/7 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (14/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.7.1.45
Use Curated BLAST to search for 2.7.1.13 or 2.7.1.45
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (319 amino acids)
>IAI46_00095 sugar kinase (Serratia liquefaciens MT49) MTTLTTAHRAQLDVVTLGEAMAMFVATQTGDLAEVDNFTKRIAGAELNVAIGLARLGLNV GWVSRVGNDTFGRFTLQQLKKEGINAQQVTVDANYPTGFQIKSKTSDGTDPSVEYFRKGS AASHLSVDDFNRDYFGSARHLHLSGVAAALSGQSLALCNHAAREMRAMGKTISFDPNLRP VLWSSQQVMIEQLNKLAFAADWVLPGLKEGQILTGQSTPEGIADFYLERGVQAVIIKTGP DGAWFKTAAGDQAAVAAIKVSNVVDTVGAGDGFAVGTISALLEGKTLKQAVQRGNKIGSL AIQAIGDSEGLPTRAALAE