Protein Info for HUW76_10185 in Fusobacterium nucleatum SB010

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 transmembrane" amino acids 16 to 36 (21 residues), see Phobius details amino acids 53 to 78 (26 residues), see Phobius details amino acids 96 to 119 (24 residues), see Phobius details amino acids 139 to 160 (22 residues), see Phobius details amino acids 171 to 192 (22 residues), see Phobius details amino acids 198 to 218 (21 residues), see Phobius details amino acids 241 to 262 (22 residues), see Phobius details amino acids 274 to 296 (23 residues), see Phobius details amino acids 318 to 340 (23 residues), see Phobius details amino acids 362 to 383 (22 residues), see Phobius details amino acids 392 to 413 (22 residues), see Phobius details amino acids 419 to 438 (20 residues), see Phobius details PF01554: MatE" amino acids 23 to 186 (164 residues), 81 bits, see alignment E=8e-27 amino acids 252 to 406 (155 residues), 87.5 bits, see alignment E=8e-29 TIGR00797: MATE efflux family protein" amino acids 23 to 420 (398 residues), 223.3 bits, see alignment E=2.4e-70

Best Hits

KEGG orthology group: None (inferred from 95% identity to fnu:FN1726)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (457 amino acids)

>HUW76_10185 MATE family efflux transporter (Fusobacterium nucleatum SB010)
MENKHNFMETESITKLLIKFSIPAIVGMFVNALYNVVDRIYIGNIKDIGHLGITGIGVVF
PVVILIFSFSLLIGIGSAAAVSLKLGMKDREEAERFLGVAVFLSFIISAVLMLLIYFYMD
KIIYFIGGSDKTFIYAKDYLFYINLGVPAAILGLVLNSVIRSDGSPKIAMGTLLLGAITN
IVLDPIFIFAFGMGVKGAAIATIISQYVSMLWTIYYFTSNKSKIKLVKKDIKFNFYKAKE
ICLLGSSAFAIQLGFSLVTYILNTVLKKYGGDTSIGAMAIVQSFMAFMAMPIFGINQGIQ
PILGYNYGAEKYKRVKEALYKGIFAATIICIIGYISVRLFSNNLIKIFTSNPELQEITKY
GLKAYTLVFPIVGFQIVSSIYFQAVGKPKMSFFISLSRQIIVMIPCLIILPIFFGLNGIW
YAAPTADSIATLITYILVKKEIKKLDKLEEILEKRNI