Protein Info for HUW76_10115 in Fusobacterium nucleatum SB010

Annotation: ATP-dependent zinc metalloprotease FtsH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 723 transmembrane" amino acids 99 to 121 (23 residues), see Phobius details amino acids 225 to 246 (22 residues), see Phobius details TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 227 to 718 (492 residues), 726.5 bits, see alignment E=8.1e-223 PF00004: AAA" amino acids 318 to 450 (133 residues), 153.8 bits, see alignment E=8.7e-49 PF17862: AAA_lid_3" amino acids 473 to 517 (45 residues), 41.3 bits, see alignment 2.3e-14 PF01434: Peptidase_M41" amino acids 532 to 717 (186 residues), 208.2 bits, see alignment E=2.8e-65

Best Hits

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 81% identity to fnu:FN1978)

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (723 amino acids)

>HUW76_10115 ATP-dependent zinc metalloprotease FtsH (Fusobacterium nucleatum SB010)
MNDNQFEKDDLKDKDDSDIHEKQENKENKEEEKSKEENHQEQDSQNEDKKEENNSENNKS
SNEGKKQEDKKQDDKYNPFTKKREDERRRVVGKAVKVNFNFKGLLMLIFIITLAVVIPSI
MDENKNQQMVDISYSDFIKNIENKKIGVVEEKDGYVYGYKASEVKYLETRSNSIKSKLGF
DGKNEVQGLKARLITNRLGEDSNLMAVINNNAAIIQSVEPPQPSLLLSIALSLLPYIIMI
GLLVFMMNRMGRGGSGGGPQIFNMGKSRAKENGENISNVTFADVAGIDEAKQELKEVVDF
LKEPEKFRKIGAKIPKGVLLLGQPGTGKTLLAKAVAGEAKVPFFSMSGSEFVEMFVGVGA
SRVRDLFNKARKNAPCIVFIDEIDAVGRKRGTGQGGGNDEREQTLNQLLVEMDGFGTDET
IIVLAATNRADVLDKALTRPGRFDRQVYVDMPDLRGREAILKVHAKNKKFAADVDFNIIA
KKTAGMAGADLANILNEGAILAARAGRTEITMADLEEASEKVQMGPEKRSKVIADIDKKI
TAYHEAGHAVVNYMQGGETKVHKITMIPRGPAGGYTMPLPAEERMYHSKKQFLDEMSELY
GGRAAEEIIFGKEYITTGASSDIQRATAIARYIVTQIGMDEKFGPILLDGTQDGDMFQRK
YYSEQTGKEIDDEIRRLVKERYQKAIDILNENRNKLEEVTRVLLEKETIMGPEFEAIMAD
KNI