Protein Info for HUW76_08770 in Fusobacterium nucleatum SB010

Annotation: bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 96% identical to PYRR_FUSNN: Bifunctional protein PyrR (pyrR) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)

KEGG orthology group: K02825, pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC: 2.4.2.9] (inferred from 96% identity to fnu:FN0418)

Predicted SEED Role

"Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR" in subsystem De Novo Pyrimidine Synthesis or LMPTP YwlE cluster (EC 2.4.2.9)

MetaCyc Pathways

pyrimidine nucleobases salvage I (1/1 steps found)
superpathway of pyrimidine nucleobases salvage (3/4 steps found)
pyrimidine nucleobases salvage II (1/2 steps found)
superpathway of pyrimidine ribonucleosides salvage (5/10 steps found)

KEGG Metabolic Maps

Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.9

Use Curated BLAST to search for 2.4.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (173 amino acids)

>HUW76_08770 bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR (Fusobacterium nucleatum SB010)
MKILLDENGIRRSITRISYEIIERNKTVDNIVLVGIKSRGDILAERIKQKLMELENIDVP
LETIDITYYRDDIDRKNFELDIKDIEFKTNLTGKVVVIVDDVLYTGRTIRAGLDAILSKS
RPAKIQLACLIDRGHRELPIRADFIGKNIPTSHSENIEVYLKELDGKEEVVIL