Protein Info for HUW76_08280 in Fusobacterium nucleatum SB010

Annotation: winged helix-turn-helix transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 125 PF12840: HTH_20" amino acids 44 to 90 (47 residues), 31.7 bits, see alignment E=1.2e-11 PF01022: HTH_5" amino acids 45 to 90 (46 residues), 59.5 bits, see alignment E=2.3e-20

Best Hits

Swiss-Prot: 41% identical to ZIAR_SYNY3: Transcriptional repressor SmtB homolog (ziaR) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K03892, ArsR family transcriptional regulator (inferred from 96% identity to fnu:FN0260)

Predicted SEED Role

"Cadmium efflux system accessory protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (125 amino acids)

>HUW76_08280 winged helix-turn-helix transcriptional regulator (Fusobacterium nucleatum SB010)
MKSTKIVNSCDCDSVNQELVDKVKKKFLEDEILGDLSDFFKVIGDGTRIRILWALDVSEM
CVCDIANVLNMTKSAVSHQLRALRDADLVKFRRAGKEVLYSLSDNHVKEIFEQGLIHIQE
DKGDE