Protein Info for HUW76_07980 in Fusobacterium nucleatum SB010

Annotation: TolC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 signal peptide" amino acids 1 to 16 (16 residues), see Phobius details TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 17 to 449 (433 residues), 210.1 bits, see alignment E=2.8e-66 PF02321: OEP" amino acids 57 to 241 (185 residues), 70.8 bits, see alignment E=7e-24 amino acids 271 to 448 (178 residues), 103 bits, see alignment E=8.8e-34

Best Hits

Swiss-Prot: 46% identical to TDEA_AGGAC: Toxin and drug export protein A (tdeA) from Aggregatibacter actinomycetemcomitans

KEGG orthology group: None (inferred from 48% identity to pmu:PM0527)

Predicted SEED Role

"RND efflux system, outer membrane lipoprotein CmeC" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>HUW76_07980 TolC family protein (Fusobacterium nucleatum SB010)
MKKIIIVITLLSTMACTNTNINNSYKQNKEEFQVYQEISNNYKIDKEWWKEYNNSELNNI
MNIALKNNSDLKKAAINVNKALYQANLLGADLVPSFSSSLGSSASKNIKTGGSSAIKHSA
SISLNYEIDLWRKLSNAKNAQEWEYQATTEDLEAAKLSLINNVVNTYFNIVYLNDAISIL
NDKIEQYEKINTVMKNKYQYGVNSELEYLQSEQSLTNLKNTLLTYQNEKTEQEQTLRDLL
NLKPEENIEIKTKNLLSFKDIGVNLDVPISVIANRPDVKAYEYRLSKAFKDVKATQAKLY
PSVTIQSTLSSSGNKVDNALSVPIGLASINISLPFLNWNTLKWNIKIDEASYENAKVDFE
KSIVSSLNEIDTYYKSYQKANSSYALQEKNLKSQKEITKHYKNRYDNGNVEFKSWLEALV
NEKDSELNLLKAKFDIIQAENKIYQAMGGKAK