Protein Info for HUW76_07885 in Fusobacterium nucleatum SB010
Annotation: aldehyde dehydrogenase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 55% identical to ALDA_STAA8: Putative aldehyde dehydrogenase AldA (aldA) from Staphylococcus aureus (strain NCTC 8325)
KEGG orthology group: None (inferred from 94% identity to fnu:FN0454)MetaCyc: 49% identical to aldehyde dehydrogenase B (Escherichia coli K-12 substr. MG1655)
Aldehyde dehydrogenase (NADP(+)). [EC: 1.2.1.4]
Predicted SEED Role
"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)
MetaCyc Pathways
- methylglyoxal degradation V (2/3 steps found)
- L-lactaldehyde degradation (aerobic) (1/2 steps found)
- pyruvate fermentation to acetate VIII (1/2 steps found)
- L-carnitine degradation II (1/3 steps found)
- methylglyoxal degradation IV (1/3 steps found)
- cytosolic NADPH production (yeast) (2/5 steps found)
- lactate biosynthesis (archaea) (2/5 steps found)
- 1,2-dichloroethane degradation (1/4 steps found)
- mitochondrial NADPH production (yeast) (1/5 steps found)
- superpathway of methylglyoxal degradation (3/8 steps found)
- L-rhamnose degradation II (2/8 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (2/8 steps found)
- superpathway of fucose and rhamnose degradation (3/12 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.22 or 1.2.1.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (491 amino acids)
>HUW76_07885 aldehyde dehydrogenase family protein (Fusobacterium nucleatum SB010) MENILKKSYKMFINGKWVNSSNGIMVKTYAPYNNELLSEFPDASENDVDLAVKSAKEAFK IWRKTTVKERAKILNEIADIIDENKDLLATVETMDNGKPIRETKLVDIPLAATHFRYFAA CILADEGKATILDEKFLSIILKEPIGVVGQIIPWNFPFLMAAWKLAPALAAGDTVVLKPS SSTTLSLLVLMELIQNVIPKGVVNLITGKGSTAGEFLKNHPDLDKLAFTGSTAVGRDIAL AAAEKLIPATLELGGKSANIILDDADMEKALEGAQLGILFNQGQVCCAGSRIFVQEGIYD EFIEKLVKKFENIKIGNPLDPTTVMGSQIDARQVKTILDYVEIAKQEGGTILTGGVKYTE NGCDKGNFVRPTLITNVKNTCRVSQEEIFGPVAVVIKFKTDDEVIAQANENEYGLGGAVF TKNINRAFRIAREIQTGRVWINTYNQIPEHAPFGGYKKSGIGRETHKVILEHYTQMKNIL IDLEEGTSGLY