Protein Info for HUW76_07695 in Fusobacterium nucleatum SB010

Annotation: CidA/LrgA family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 118 transmembrane" amino acids 13 to 40 (28 residues), see Phobius details amino acids 52 to 71 (20 residues), see Phobius details amino acids 85 to 105 (21 residues), see Phobius details PF03788: LrgA" amino acids 13 to 105 (93 residues), 100.9 bits, see alignment E=1.6e-33

Best Hits

Swiss-Prot: 40% identical to CIDA_BACVZ: Holin-like protein CidA (cidA) from Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42)

KEGG orthology group: K06518, holin-like protein (inferred from 90% identity to fnu:FN0467)

Predicted SEED Role

"Antiholin-like protein LrgA" in subsystem Murein hydrolase regulation and cell death

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (118 amino acids)

>HUW76_07695 CidA/LrgA family protein (Fusobacterium nucleatum SB010)
MIGEFMLILVINYVGILISTVLHFPLPGTITALLLLFLLLKFKILKLEKIENAANFLLLN
MTLFFMPPTVKIIDSYDLLEKDLVKIIIIIVVSTFLTMGITGKVVQMMIDYREKKGLK