Protein Info for HUW76_07570 in Fusobacterium nucleatum SB010

Annotation: acetyl-CoA C-acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00108: Thiolase_N
  • amino acids 4 to 263 (260 residues), 319.5 bits, E=1.7e-99
• TIGR01930: acetyl-CoA C-acyltransferase
  • amino acids 6 to 399 (394 residues), 467 bits, E=2.4e-144
• PF02803: Thiolase_C
  • amino acids 270 to 399 (130 residues), 149.1 bits, E=4.8e-48

Best Hits

Swiss-Prot: 54% identical to THIL_CHRVO: Acetyl-CoA acetyltransferase (phaA) from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)

KEGG orthology group: K00626, acetyl-CoA C-acetyltransferase [EC: 2.3.1.9] (inferred from 96% identity to fnu:FN0495)

MetaCyc: 55% identical to acetyl-CoA C-acetyltransferase (Pseudomonas simiae)
Acetyl-CoA C-acyltransferase. [EC: 2.3.1.16, 2.3.1.9]

Predicted SEED Role

"3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)" (EC 2.3.1.16, EC 2.3.1.9)

MetaCyc Pathways

• L-lysine fermentation to acetate and butanoate (10/10 steps found)
• acetoacetate degradation (to acetyl CoA) (2/2 steps found)
• superpathway of Clostridium acetobutylicum acidogenic fermentation (7/9 steps found)
• pyruvate fermentation to acetone (4/5 steps found)
• pyruvate fermentation to hexanol (engineered) (8/11 steps found)
• acetyl-CoA fermentation to butanoate (5/7 steps found)
• pyruvate fermentation to butanoate (5/7 steps found)
• benzoyl-CoA biosynthesis (2/3 steps found)
• ketolysis (2/3 steps found)
• L-glutamate degradation V (via hydroxyglutarate) (7/10 steps found)
• pyruvate fermentation to butanol II (engineered) (4/6 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (9/13 steps found)
• glycerol degradation to butanol (11/16 steps found)
• glutaryl-CoA degradation (3/5 steps found)
• isopropanol biosynthesis (engineered) (3/5 steps found)
• pyruvate fermentation to butanol I (5/8 steps found)
• (2S)-ethylmalonyl-CoA biosynthesis (2/4 steps found)
• polyhydroxybutanoate biosynthesis (1/3 steps found)
• 5,6-dehydrokavain biosynthesis (engineered) (6/10 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (11/17 steps found)
• fatty acid salvage (3/6 steps found)
• valproate β-oxidation (5/9 steps found)
• (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) (2/5 steps found)
• 4-hydroxybenzoate biosynthesis III (plants) (2/5 steps found)
• fatty acid β-oxidation II (plant peroxisome) (2/5 steps found)
• ethylbenzene degradation (anaerobic) (1/5 steps found)
• fatty acid β-oxidation VII (yeast peroxisome) (1/5 steps found)
• ketogenesis (1/5 steps found)
• L-glutamate degradation VII (to butanoate) (6/12 steps found)
• fatty acid β-oxidation I (generic) (2/7 steps found)
• fatty acid β-oxidation VI (mammalian peroxisome) (2/7 steps found)
• superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (4/10 steps found)
• 10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast) (1/6 steps found)
• 4-ethylphenol degradation (anaerobic) (1/6 steps found)
• L-isoleucine degradation I (1/6 steps found)
• propanoate fermentation to 2-methylbutanoate (1/6 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (16/27 steps found)
• 2-methylpropene degradation (2/8 steps found)
• mevalonate pathway I (eukaryotes and bacteria) (1/7 steps found)
• mevalonate pathway II (haloarchaea) (1/7 steps found)
• benzoate biosynthesis I (CoA-dependent, β-oxidative) (2/9 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (14/26 steps found)
• 2-deoxy-D-ribose degradation II (1/8 steps found)
• isoprene biosynthesis II (engineered) (1/8 steps found)
• mevalonate pathway III (Thermoplasma) (1/8 steps found)
• mevalonate pathway IV (archaea) (1/8 steps found)
• 2-methyl-branched fatty acid β-oxidation (5/14 steps found)
• oleate β-oxidation (20/35 steps found)
• 3-phenylpropanoate degradation (2/10 steps found)
• 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast) (2/10 steps found)
• methyl tert-butyl ether degradation (2/10 steps found)
• 4-oxopentanoate degradation (1/9 steps found)
• ethylmalonyl-CoA pathway (2/11 steps found)
• superpathway of glyoxylate cycle and fatty acid degradation (4/14 steps found)
• (8E,10E)-dodeca-8,10-dienol biosynthesis (1/11 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (6/18 steps found)
• 10-cis-heptadecenoyl-CoA degradation (yeast) (1/12 steps found)
• 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast) (1/12 steps found)
• L-tryptophan degradation III (eukaryotic) (3/15 steps found)
• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) (1/13 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
• docosahexaenoate biosynthesis III (6-desaturase, mammals) (1/14 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
• jasmonic acid biosynthesis (4/19 steps found)
• toluene degradation VI (anaerobic) (3/18 steps found)
• cholesterol degradation to androstenedione I (cholesterol oxidase) (2/17 steps found)
• sitosterol degradation to androstenedione (1/18 steps found)
• androstenedione degradation I (aerobic) (6/25 steps found)
• cholesterol degradation to androstenedione II (cholesterol dehydrogenase) (2/22 steps found)
• superpathway of testosterone and androsterone degradation (6/28 steps found)
• androstenedione degradation II (anaerobic) (4/27 steps found)
• platensimycin biosynthesis (3/26 steps found)
• superpathway of ergosterol biosynthesis I (3/26 steps found)
• superpathway of L-lysine degradation (14/43 steps found)
• superpathway of cholesterol degradation I (cholesterol oxidase) (8/42 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (16/56 steps found)
• superpathway of cholesterol biosynthesis (3/38 steps found)
• superpathway of cholesterol degradation II (cholesterol dehydrogenase) (8/47 steps found)
• superpathway of cholesterol degradation III (oxidase) (4/49 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Benzoate degradation via hydroxylation
• Biosynthesis of plant hormones
• Biosynthesis of unsaturated fatty acids
• Butanoate metabolism
• Ethylbenzene degradation
• Fatty acid elongation in mitochondria
• Fatty acid metabolism
• Geraniol degradation
• Lysine degradation
• Propanoate metabolism
• Pyruvate metabolism
• Synthesis and degradation of ketone bodies
• Terpenoid biosynthesis
• Tryptophan metabolism
• Valine, leucine and isoleucine degradation
• alpha-Linolenic acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.16 or 2.3.1.9

Protein Sequence (402 amino acids)

>HUW76_07570 acetyl-CoA C-acetyltransferase (Fusobacterium nucleatum SB010)
MSKVYVVAAKRSAIGSFLGSLAPLKPGDLGAQIVKNILEETKVDPANIDEVIVGNVLSAG
QAQGVGRQVSIRAGIPYEVPAYSVNIICGSGMKSIITAFSNIKAGEANLVIAGGTESMSG
AGFILPGAIRGGHKMADLTMKDHMILDALTDAYHNIHMGITAENIAEKYGITREEQDAFA
LESQKKAIAAVDSGRFKDEIVPVIIPNKKGDITFDTDEYPNRKTDAEKLAKLKPAFKKDG
SVTAGNASGLNDGASFVMLASEEAVKKYNLKPLVEIIATGTGGVDPLIMGMGPVPAIRKA
FNKTDLKLKDMELIELNEAFAAQSLGVIKELCKEHGVTPEWIKERTNVNGGAIALGHPVG
ASGNRITVTLIHEMKKRGVEYGLASLCIGGGMGTALILKNVK