Protein Info for HUW76_07405 in Fusobacterium nucleatum SB010
Annotation: glycerol-3-phosphate 1-O-acyltransferase PlsY
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 89% identical to PLSY_FUSNN: Glycerol-3-phosphate acyltransferase (plsY) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
KEGG orthology group: K08591, glycerol-3-phosphate acyltransferase PlsY [EC: 2.3.1.15] (inferred from 89% identity to fnu:FN0537)MetaCyc: 41% identical to acyl phosphate:glycerol-3-phosphate acyltransferase (Streptococcus pneumoniae R6)
RXN-9591 [EC: 2.3.1.275]
Predicted SEED Role
"Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria
MetaCyc Pathways
- phosphatidylglycerol biosynthesis I (6/6 steps found)
- phosphatidylglycerol biosynthesis II (6/6 steps found)
- superpathway of cardiolipin biosynthesis (bacteria) (11/13 steps found)
- CDP-diacylglycerol biosynthesis III (5/5 steps found)
- superpathway of phospholipid biosynthesis III (E. coli) (10/12 steps found)
- CDP-diacylglycerol biosynthesis I (4/4 steps found)
- CDP-diacylglycerol biosynthesis II (4/4 steps found)
- oleate biosynthesis III (cyanobacteria) (2/3 steps found)
- phosphatidate biosynthesis (yeast) (3/5 steps found)
- palmitoyl ethanolamide biosynthesis (2/6 steps found)
- superpathway of stearidonate biosynthesis (cyanobacteria) (2/6 steps found)
- diacylglycerol and triacylglycerol biosynthesis (2/7 steps found)
- stigma estolide biosynthesis (2/7 steps found)
- anandamide biosynthesis II (2/8 steps found)
- anandamide biosynthesis I (3/12 steps found)
- superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.3.1.15
Use Curated BLAST to search for 2.3.1.15 or 2.3.1.275
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (194 amino acids)
>HUW76_07405 glycerol-3-phosphate 1-O-acyltransferase PlsY (Fusobacterium nucleatum SB010) MTFFCLIILSYFFGAIPSGVWIGKIFKNIDVRDYGSKNSGATNSYRVLGAKLGIAVLIID VLKGFIPLYIASKFNLKYNDLVILGLVAILAHTFSCFISFKGGKGVATSLGVFLFLAPVI TLILLVIFILVVYFTKYISLGSITAAFLLPIFTFFTHRDTYLFTLSVVIAIFVIYRHKTN ISRLLSGTENKFKF