Protein Info for HUW76_06470 in Fusobacterium nucleatum SB010

Annotation: phosphate acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01515: PTA_PTB
  • amino acids 3 to 326 (324 residues), 404.6 bits, E=1.8e-125
• TIGR00651: phosphate acetyltransferase
  • amino acids 18 to 326 (309 residues), 373.5 bits, E=4.6e-116

Best Hits

Swiss-Prot: 51% identical to PTAS_THETC: Phosphate acetyltransferase (pta) from Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814)

KEGG orthology group: K00625, phosphate acetyltransferase [EC: 2.3.1.8] (inferred from 94% identity to fnu:FN1172)

MetaCyc: 49% identical to phosphate acetyltransferase (Clostridium kluyveri)
Phosphate acetyltransferase. [EC: 2.3.1.8]

Predicted SEED Role

"Phosphate acetyltransferase (EC 2.3.1.8)" in subsystem Ethanolamine utilization or Fermentations: Lactate or Fermentations: Mixed acid or MLST or Propanediol utilization or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Threonine anaerobic catabolism gene cluster (EC 2.3.1.8)

MetaCyc Pathways

• hexitol fermentation to lactate, formate, ethanol and acetate (17/19 steps found)
• L-lysine fermentation to acetate and butanoate (10/10 steps found)
• L-threonine degradation I (6/6 steps found)
• ethanolamine utilization (5/5 steps found)
• superpathway of N-acetylneuraminate degradation (17/22 steps found)
• pyruvate fermentation to acetate and lactate II (4/4 steps found)
• pyruvate fermentation to acetate I (3/3 steps found)
• pyruvate fermentation to acetate IV (3/3 steps found)
• pyruvate fermentation to acetate VII (3/3 steps found)
• acetate and ATP formation from acetyl-CoA I (2/2 steps found)
• superpathway of Clostridium acetobutylicum acidogenic fermentation (7/9 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (7/9 steps found)
• (S)-propane-1,2-diol degradation (4/5 steps found)
• acetylene degradation (anaerobic) (4/5 steps found)
• pyruvate fermentation to acetate and (S)-lactate I (3/4 steps found)
• heterolactic fermentation (13/18 steps found)
• acetyl-CoA fermentation to butanoate (5/7 steps found)
• pyruvate fermentation to acetate II (2/3 steps found)
• superpathway of acetate utilization and formation (2/3 steps found)
• sulfoacetaldehyde degradation I (1/2 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (5/8 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (11/17 steps found)
• sulfolactate degradation II (1/4 steps found)
• methanogenesis from acetate (2/6 steps found)
• superpathway of sulfolactate degradation (2/6 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (7/13 steps found)
• superpathway of L-alanine fermentation (Stickland reaction) (4/9 steps found)
• superpathway of L-threonine metabolism (10/18 steps found)
• superpathway of taurine degradation (1/6 steps found)
• mixed acid fermentation (8/16 steps found)
• gallate degradation III (anaerobic) (4/11 steps found)
• purine nucleobases degradation II (anaerobic) (10/24 steps found)
• superpathway of methanogenesis (2/21 steps found)
• superpathway of L-lysine degradation (14/43 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Pyruvate metabolism
• Taurine and hypotaurine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.8

Protein Sequence (334 amino acids)

>HUW76_06470 phosphate acetyltransferase (Fusobacterium nucleatum SB010)
MSFLGQVRKKALQAHRRIVLPETNDERVIRAASQILKEGLAQVILVGNQEAIMHSAKAYE
VSLSGAKIVDPYNFERFNDYVNKLVELRAKKGMTPEEAKKLLLNNPTFFGAMLVKMGDAD
GMVSGSASPTANVLRAAIQVIGTQPGVKTVSSVFIMELSQFKDLFGSILVFGDCSVIPVP
TSEQLADIATSAAETAVKIAGINPRVALLTFSTKGSAKHECVDRVIEAGRILRERKVQFR
FDDELQADAALVKSVGEIKAPLSDVSGNANVLIFPSLSAGNIGYKLVQRLAGANAYGPII
QGLNAPVNDLSRGCSVEDIVVLTAITSAQACVDC