Protein Info for HUW76_04605 in Fusobacterium nucleatum SB010

Annotation: prolyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 323 TIGR01249: prolyl aminopeptidase" amino acids 11 to 312 (302 residues), 322.8 bits, see alignment E=1.1e-100 PF00561: Abhydrolase_1" amino acids 38 to 299 (262 residues), 89.9 bits, see alignment E=2.2e-29 PF12146: Hydrolase_4" amino acids 62 to 300 (239 residues), 34.9 bits, see alignment E=1.1e-12

Best Hits

KEGG orthology group: K01259, proline iminopeptidase [EC: 3.4.11.5] (inferred from 93% identity to fnu:FN0752)

Predicted SEED Role

"Proline iminopeptidase (EC 3.4.11.5)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 3.4.11.5)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (323 amino acids)

>HUW76_04605 prolyl aminopeptidase (Fusobacterium nucleatum SB010)
MGNYDFYPAIEPFKSYMLPVSDIHSIYVEECGNPNGEPIIFLHGGPGAGCGKKARRFFDP
EYYHIILFDQRGCGRSIPFVELKENNIFYSVEDMEKIRLHIGIDKWTIFAGSYGSTLGLT
YAIHYPEKVKRMVLQGIFLANEEDVKWYFQKGISEIYPAEFKIFKDFIPKAEQDNLLEAY
HKIFFSNDIKLRNEAIKIWSRFELRTMESEFTWSSDEEVQNYEISLALIEAHYFYNKMFW
NDSEYILNRAKIIKDIPIQIAHGRFDLNTRVVSAYKLAEKLNNCELIIVEGVGHSPFTEK
MSKVLIKFLEDIKELNYKDEGNG