Protein Info for HUW76_04570 in Fusobacterium nucleatum SB010

Annotation: HD family phosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 690 transmembrane" amino acids 36 to 56 (21 residues), see Phobius details amino acids 273 to 298 (26 residues), see Phobius details amino acids 311 to 333 (23 residues), see Phobius details amino acids 339 to 364 (26 residues), see Phobius details amino acids 371 to 388 (18 residues), see Phobius details amino acids 397 to 419 (23 residues), see Phobius details amino acids 429 to 451 (23 residues), see Phobius details PF07697: 7TMR-HDED" amino acids 63 to 268 (206 residues), 101.5 bits, see alignment E=1e-32 PF07698: 7TM-7TMR_HD" amino acids 276 to 459 (184 residues), 102.3 bits, see alignment E=5e-33 TIGR00277: HDIG domain" amino acids 481 to 579 (99 residues), 76.3 bits, see alignment E=6.4e-26 PF01966: HD" amino acids 484 to 625 (142 residues), 54 bits, see alignment E=3.1e-18

Best Hits

KEGG orthology group: K07037, (no description) (inferred from 94% identity to fnu:FN0745)

Predicted SEED Role

"Membrane protein containing HD superfamily hydrolase domain, YQFF ortholog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (690 amino acids)

>HUW76_04570 HD family phosphohydrolase (Fusobacterium nucleatum SB010)
MKKFTIFGFKFLFDIKKKDSSDEEKYSDSYFLKEKVFYLILALFLITLSSKIPILFRNNN
YMVGDVVKSDIYSPKTIVFRDKIGKDKIIQDMIDRLDKDYIYSSDAADIYKEEFENFHKE
IIAIKKGNLKSFDYSGFERKTGKVMPESLINKLLEEDEEKIDEIFSKLDGELENAYKAGI
YKEKNSIRINEPAKSEIDALEPFEREIINNFLIPNYIYDEAKTKNTINEKVSQIHDQYIE
IKAGTLIAKTGEILTDRKIDILDKLGIYNYKMSIFIIALNLIFLLVISSVFNVVTIKFYS
KEILEKNKYRAMMLLTIGTLLAFRIVPNSMIYLLPLDTMLLLLVFIVKPRFSIFLTMMVI
SYMLPITDYDLKYFTIQSIAILATGFLSKNISTRSSVIAIGIQLAILKILLYLILSFFSV
EESYGVALNTIKIFISGLFSGMLAIALLPYFERTFNILTVFKLIELADLSHPLLRKLSIE
APGTFQHSMMVATLSENAVVEIGGDPIFTRVACYYHDIGKTKRPQYYVENQTGGKNLHND
ISPFMSKMIILAHTREGAEMGKKYKIPKEIRDIMFEHQGTTLLAYFYNKAKEIDPNIPEE
EFRYSGPKPQTKESAVILLADSIEAAVRSLDVKDPVKIEQMVRKIVDSKIRDNQLSDANI
TFKEIEIIVNSFLKTFGAIYHERIKYPGQK