Protein Info for HUW76_04295 in Fusobacterium nucleatum SB010

Annotation: sodium/panthothenate symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 484 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 45 to 66 (22 residues), see Phobius details amino acids 76 to 96 (21 residues), see Phobius details amino acids 124 to 146 (23 residues), see Phobius details amino acids 158 to 177 (20 residues), see Phobius details amino acids 188 to 206 (19 residues), see Phobius details amino acids 239 to 261 (23 residues), see Phobius details amino acids 274 to 297 (24 residues), see Phobius details amino acids 319 to 343 (25 residues), see Phobius details amino acids 369 to 386 (18 residues), see Phobius details amino acids 392 to 415 (24 residues), see Phobius details amino acids 422 to 441 (20 residues), see Phobius details amino acids 449 to 469 (21 residues), see Phobius details TIGR02119: sodium/pantothenate symporter" amino acids 5 to 472 (468 residues), 753.3 bits, see alignment E=1.2e-230 TIGR00813: transporter, solute:sodium symporter (SSS) family" amino acids 38 to 431 (394 residues), 259.9 bits, see alignment E=4.4e-81 PF00474: SSF" amino acids 38 to 432 (395 residues), 321.4 bits, see alignment E=4.4e-100

Best Hits

Swiss-Prot: 47% identical to PANF_ECOLI: Sodium/pantothenate symporter (panF) from Escherichia coli (strain K12)

KEGG orthology group: K14392, sodium/pantothenate symporter (inferred from 93% identity to fnu:FN0685)

MetaCyc: 47% identical to pantothenate:Na+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-117

Predicted SEED Role

"Pantothenate:Na+ symporter (TC 2.A.21.1.1)" in subsystem Coenzyme A Biosynthesis (TC 2.A.21.1.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (484 amino acids)

>HUW76_04295 sodium/panthothenate symporter (Fusobacterium nucleatum SB010)
MNKILIIIPIAIYLIAMLYIAYRVNNIKNSSKNFTNEYYLGSRSMGGFVLAMTIVATYVG
ASSFIGGPGIAYNLGLGWVLLACIQVPTAFFTLGVLGKKLSIISRKLNAITIFDVLKARY
NNNFLNVLSSILLIVFFISAIVAQFIGGARLFEAVTGLSYLTGLIIFSSVVIIYTTFGGF
RAVTLTDAIQAVVMFTATIVLFIVILKNGNGMENIMMKIKDINPNLLRPDSGGNIAKPFI
MSFWILVGIGVLGLPATTVRCMAFKDTKAMHNAMIIGTSLVGILVLGMHLVGVMGRAVIP
DLQEVDKIIPILALKNLYPILAGVFIGGPLAAVMSSVDSLLIVSSSTLIKDLYVTYLDKN
ASENKIKKISMWTSFLIGVLVFVLSIKPISLIAWVNLFAFGGQEIIFFCPLILGLYWKRA
NATGAIISIFSGIITYLTLEILKTKIYSLHNIVPGLIVAITFFIVGSYFGKKSDEKTIKI
FFEY