Protein Info for HUW76_03860 in Fusobacterium nucleatum SB010

Annotation: aminoacyl-histidine dipeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 TIGR01893: Xaa-His dipeptidase" amino acids 8 to 486 (479 residues), 716 bits, see alignment E=1e-219 PF01546: Peptidase_M20" amino acids 73 to 484 (412 residues), 50.4 bits, see alignment E=2.7e-17 PF07687: M20_dimer" amino acids 209 to 293 (85 residues), 49.8 bits, see alignment E=2.9e-17

Best Hits

KEGG orthology group: K01270, aminoacylhistidine dipeptidase [EC: 3.4.13.3] (inferred from 92% identity to fnu:FN1277)

Predicted SEED Role

"Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3)" (EC 3.4.13.3)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.13.3

Use Curated BLAST to search for 3.4.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (486 amino acids)

>HUW76_03860 aminoacyl-histidine dipeptidase (Fusobacterium nucleatum SB010)
MSRKLENLKPERVFYYFEELSKIPRESANEKAVSDFLVDTAKKLGLEVYQDKINNIVIKK
PATKGYENSDGVILQGHMDMVCEKELDSNHNFKTDGIDLIVDGKFLRANKTTLGADNGIA
VAMGLAILEDNTIEHPEIELLVTVEEETTMRGAMELEENILTGKMLINIDSEEEGWVTVG
SAGGREVDIIFNEEKEKFENANSDFYRLEVKNLFGGHSGAEIHKNRLNANKVMSEVISEL
KKNFDIKLCDIKGGSKDNAIPRECYFDIAVDKSSSQNFINKSKEIFENFKNKYIGQDPNI
TFEISDLKNKYDKIYSKNLFEKVLGLVKDLPTGVNTWLKEYPDIVESSDNLAIVKVIDDK
ITVIVSLRSSEPSVLDSLEEKITTVAKKYNASYKVSGGYPEWRFKPISRLRDTAVKTYQD
LFNEKMQVAVIHAGLECGAISMHYPNLDMISIGPNIYDVHTPKEKMEIASVEKYYKYLVE
LLKNLK