Protein Info for HUW76_02535 in Fusobacterium nucleatum SB010

Annotation: glutaconyl-CoA decarboxylase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01039: Carboxyl_trans
  • amino acids 55 to 570 (516 residues), 378.8 bits, E=1.9e-117

Best Hits

Swiss-Prot: 71% identical to GCDA_ACIFV: Glutaconyl-CoA decarboxylase subunit alpha (gcdA) from Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)

KEGG orthology group: K01615, glutaconyl-CoA decarboxylase [EC: 4.1.1.70] (inferred from 96% identity to fnu:FN0204)

MetaCyc: 71% identical to GcdA (Acidaminococcus fermentans)
RXN-19739 [EC: 7.2.4.5]

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2); Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2, EC 6.4.1.3)

MetaCyc Pathways

• L-glutamate degradation V (via hydroxyglutarate) (7/10 steps found)
• L-glutamate degradation XI (reductive Stickland reaction) (4/7 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• propanoyl CoA degradation I (1/3 steps found)
• 2-oxobutanoate degradation I (1/4 steps found)
• jadomycin biosynthesis (3/9 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (2/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (6/17 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (6/18 steps found)
• 3-hydroxypropanoate cycle (2/13 steps found)
• superpathway of L-methionine salvage and degradation (4/16 steps found)
• methylaspartate cycle (4/19 steps found)
• superpathway of the 3-hydroxypropanoate cycle (2/18 steps found)
• mycolate biosynthesis (18/205 steps found)
• superpathway of mycolate biosynthesis (19/239 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Butanoate metabolism
• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.70, 6.4.1.2

Use Curated BLAST to search for 4.1.1.70 or 6.4.1.2 or 6.4.1.3 or 7.2.4.5

Protein Sequence (584 amino acids)

>HUW76_02535 glutaconyl-CoA decarboxylase subunit alpha (Fusobacterium nucleatum SB010)
MNYSMPKYFQNMPQVGNSLVNIDEANENAVREIEDAIAQSIQAIQDSGTPDEKIHDKGQM
TALERVAELVDEGTWYPLNSLYNPEDFETGTGIVKGLGRIGGKWAVVVASDNKKIVGAWV
PGQADNLLRASDTAKCLGIPLVYVLNCSGVKLDEQEKVYANRRGGGTPFFRNAELQQLGI
PVIVGIYGTNPAGGGYHSISPTILIAHKDANMAVGGAGIVGGMNPKGYIDMEGAVQIAEA
TIAAKKVEVPGTIHVHYDKTGFFREVYDDEIGVIDGIKKYMDYLPSYDLEFFRVDEPTEP
LFDPNDLYSIIPMNQKKTYNIYDVIGRLFDNSEFSEYKKGYGPEVVTGIAKVDGLLVGVV
ANAQGLLMNYPEYREKSVGIGGKLYRQGLIKMSEFVTLCSRDRLPIVWLQDTSGIDVGNP
AEEAELLGLGQSLIYSIENSHVPQIEITIRKGSAAAHYVLGGPQGNNTNAFSLGTAATEV
YVMNGETAASAMYSRRLAKDYKAGKDLQPTIDKMNQLINEYTAKSRPAYCAKTGMVDEIV
PLYDLRGYIQAFANAVYQNPKSICAFHQMILPRAIREFETYTKK