Protein Info for HUW76_02280 in Fusobacterium nucleatum SB010

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 transmembrane" amino acids 12 to 37 (26 residues), see Phobius details amino acids 60 to 78 (19 residues), see Phobius details amino acids 89 to 110 (22 residues), see Phobius details amino acids 130 to 152 (23 residues), see Phobius details amino acids 162 to 184 (23 residues), see Phobius details amino acids 192 to 214 (23 residues), see Phobius details amino acids 253 to 272 (20 residues), see Phobius details amino acids 274 to 300 (27 residues), see Phobius details amino acids 317 to 336 (20 residues), see Phobius details amino acids 356 to 377 (22 residues), see Phobius details amino acids 386 to 430 (45 residues), see Phobius details PF01554: MatE" amino acids 18 to 176 (159 residues), 85.8 bits, see alignment E=2.6e-28 amino acids 243 to 404 (162 residues), 82.1 bits, see alignment E=3.6e-27 TIGR00797: MATE efflux family protein" amino acids 18 to 417 (400 residues), 168.1 bits, see alignment E=1.5e-53 PF14667: Polysacc_synt_C" amino acids 133 to 238 (106 residues), 32.3 bits, see alignment E=1e-11

Best Hits

KEGG orthology group: None (inferred from 92% identity to fnu:FN0162)

Predicted SEED Role

"Na+ driven multidrug efflux pump"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>HUW76_02280 MATE family efflux transporter (Fusobacterium nucleatum SB010)
MNSIGNVGKKALISLTIPIFFELLLVTVVGNIDTIMLGYYSDKAVGAIGGITQLLNIQNV
IFSFINLATAILTAQFLGARDYKRVKQVISVSLVLNILLGVVLGGIYLFFWRGLLQKINL
PEELVGIGKYYFQMVGGLCVFQGIILSCGAILKSHGRPTETLIINVGVNILNILGNGMFI
FGWLGMPVLGTTGVGISTVVSRGIGCVAAFYMMCKYCNFTFRKKYIKPFPFKIVKNILSI
GFPTAGENLSWNVGQLLIVAMVNTMGTTIIASRTYLMLISNFVMTLSIALGQGTAIQVGH
LVGAGEVKEVYSKCLKSVKIAFVFAFVATSIVCFLRKPIMNIFTTNPDILSASLKIFPLM
IILEMGRVFNIVIINSLHAAGDIKFPMFMSIICVYTVAVLFSYIFGISLGWGLAGIWIAN
AMDEWIRGIAMYLRWKSRKWQNKSFV