Protein Info for HUW76_01065 in Fusobacterium nucleatum SB010

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 768 PF02190: LON_substr_bdg" amino acids 4 to 194 (191 residues), 158.6 bits, see alignment E=5.1e-50 TIGR00763: endopeptidase La" amino acids 6 to 766 (761 residues), 902.9 bits, see alignment E=1.1e-275 PF07728: AAA_5" amino acids 345 to 479 (135 residues), 39.3 bits, see alignment E=1.6e-13 PF00004: AAA" amino acids 345 to 483 (139 residues), 91.2 bits, see alignment E=2e-29 PF05362: Lon_C" amino acids 564 to 767 (204 residues), 267.7 bits, see alignment E=1.5e-83 PF13541: ChlI" amino acids 614 to 735 (122 residues), 31.4 bits, see alignment E=4e-11

Best Hits

Swiss-Prot: 97% identical to LON_FUSNN: Lon protease (lon) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 97% identity to fnu:FN2014)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (768 amino acids)

>HUW76_01065 endopeptidase La (Fusobacterium nucleatum SB010)
MLKAPFLPIRDLVIFPNVVTPIYVGRANSIATLEKAIANKTKLVLGLQKDASQENPTFDG
DIYEVGVIANIVQIIRMPNNNIKVLVEAENRVRIKDIKKEENEYVTTYTVIEETLKDSKE
TEAIYRKVFTRFEKYVSMIGKFSSELILNLKKIEDYSNGLDIMASNLNISSEKKQEILEI
SNVRDRGYRILDEIVAEMEIASLEKTIDDKVKTKMNEAQRAYYLKEKISVMKEELGDFSQ
DDDVIEIVDRLKNADIPKEVREKLEVEVKKLSKMQPFSAESSVIRNYIEAVLDLPWNSQT
NDALDLKKASEILERDHYGLKDAKEKVLDYLAVKKLNPSMNGVILCLAGPPGIGKTSLVK
SIAESMGRKFVRVSLGGVRDEAEIRGHRRTYVGSMPGKIMKAMKEAGTNNPVMLLDEIDK
MSNDFKGDPASAMLEVLDPEQNKNFEDHYIDMPFDLSKVFFVATANDLRNVSAPLRDRMD
ILQLSSYTEFEKLHIAQKFLLKQAQKENGLANIDIKIPDKVMFKLIDEYTREAGVRNLKR
EIVNICRKLAREVVEKDIKKFNLKAADLEKYLGKAKFRPEKSRKAVGKVGVVNGLAWTAV
GGVTLDVQGVDTPGKGEVTLTGTLGNVMKESASVAMTYVKANLKKYPPKDKNFFKDRTIH
LHFPDGATPKDGPSAGITITTAIVSVLTNKKVRQDIAMTGEITITGDVLAIGGVREKVIG
AHRAGIKEVILPEDNRVDTDEIPDELKSTMKIHFAKTYDDVSKLVFVK