Protein Info for HMPREF1181_RS16795 in Bacteroides stercoris CC31F

Annotation: HAD-IC family P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 554 transmembrane" amino acids 42 to 62 (21 residues), see Phobius details amino acids 69 to 87 (19 residues), see Phobius details amino acids 99 to 120 (22 residues), see Phobius details amino acids 132 to 154 (23 residues), see Phobius details amino acids 166 to 188 (23 residues), see Phobius details amino acids 195 to 219 (25 residues), see Phobius details amino acids 509 to 528 (20 residues), see Phobius details amino acids 534 to 552 (19 residues), see Phobius details PF00122: E1-E2_ATPase" amino acids 159 to 228 (70 residues), 50.2 bits, see alignment E=2.3e-17 TIGR01494: HAD ATPase, P-type, family IC" amino acids 161 to 527 (367 residues), 190.9 bits, see alignment E=1.6e-60 PF00702: Hydrolase" amino acids 246 to 462 (217 residues), 99.8 bits, see alignment E=2.7e-32

Best Hits

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (554 amino acids)

>HMPREF1181_RS16795 HAD-IC family P-type ATPase (Bacteroides stercoris CC31F)
MNNILKNVCSAQKLHGAEHAGSMEQREMEERNSRYRCLKMKAAAAWALAVLLSLLSVFGG
EVSYVNEIQMSLAALVLLFPGNAFYAAARKQLCAGRIGLDTLIAFGASVAFLFSLFNTFF
PDYWLRVGLHPYVYYEVAVLVVAVGLTGKVFRFLPEERHGADRIARIFFPVLAGTAVAVF
FIWIFWGGMTAVPHAFYAVVSVFIVACPCALGLVAPLALTRGIGRAADMHIRIKDSLALE
RLDKADVVVFDKTGTLTEGQPTVTAWLWAQYQEEDFKRILLATEMNSPDPLAAAITAALR
EERITPAPLDGCGVLKGKGVKSLCNGTEYWVGSHKLLKDYRAYLSDVLGDMLVEYESEGN
SIVYFGREDELLAIIAVKDRLKATASGVVKELRGQGLDICMLTGDGERTASAIAGKLGII
RYMSDAQPEDKEAFICELRLQGKKVVMVGDGVNDAQALVAADVSIAAGASAGDGLADKAM
IVMKSADLQSLPRLFGLSRHTLRLMRRNFFRTMAFHLAGVLVAAGILYPVYGILLTPMLA
VTVIALSCIMPVKG