Protein Info for HMPREF1181_RS16585 in Bacteroides stercoris CC31F

Annotation: Na+/H+ antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 67 to 85 (19 residues), see Phobius details amino acids 103 to 122 (20 residues), see Phobius details amino acids 134 to 153 (20 residues), see Phobius details amino acids 162 to 182 (21 residues), see Phobius details amino acids 188 to 205 (18 residues), see Phobius details amino acids 215 to 245 (31 residues), see Phobius details amino acids 307 to 327 (21 residues), see Phobius details amino acids 339 to 360 (22 residues), see Phobius details amino acids 377 to 400 (24 residues), see Phobius details amino acids 412 to 433 (22 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 13 to 429 (417 residues), 447.8 bits, see alignment E=1.4e-138 TIGR00773: Na+/H+ antiporter NhaA" amino acids 14 to 429 (416 residues), 392 bits, see alignment E=1.3e-121

Best Hits

Swiss-Prot: 75% identical to NHAA_BACFR: Na(+)/H(+) antiporter NhaA (nhaA) from Bacteroides fragilis (strain YCH46)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 82% identity to bhl:Bache_2571)

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (437 amino acids)

>HMPREF1181_RS16585 Na+/H+ antiporter NhaA (Bacteroides stercoris CC31F)
MIILRTVKNISSLNIAASVLLFLAAILAAVVANSSLSPVYQDFLLQELHLRIGNFNLFSH
GGHPLKMIEFINDCLMTVFFLAVGLEIKRELLVGELSSVRKAALPFIAACGGMVVPVVIY
ALSVASGTPETRGMAIPMATDIAFSLGVLSLLGKRVPLSLKIFLTAFAVVDDIGGILVIA
LFYSADVAYGYLIAAAVLYVFLYYMGKFGVTQKIFFLFFGVIIWYLFLQSGIHSTISGVI
LAFVIPARPRLDAGKYIERIRDIIGEFPVSKSDNIVLTNAQIATLKQVERASDYVISPLQ
SLEDNLHGAVSFVILPLFAFANAGVVFSGSGSIVGDVSIAVAAGLLLGKFLGIYLFTWLA
VKSGVALMPAGMNWKNIAGVSLLGGIGFTVSLFIANLSFADEYPELLNQAKFGVLVGTVL
AGVLGYVVLNWVLPERD